在一家三级护理中心内科就诊的服用二甲双胍的 2 型糖尿病患者中维生素 B12 缺乏。
Vitamin B12 Deficiency among Metformin Treated Type 2 Diabetic Mellitus Patients Visiting the Department of Medicine of a Tertiary Care Centre.
机构信息
Department of Medicine, Birat Medical College Teaching Hospital, Biratnagar, Morang, Nepal.
Department of Community Medicine, Nepalgunj Medical College, Nepalgunj, Banke.
出版信息
JNMA J Nepal Med Assoc. 2023 Nov 1;61(267):861-863. doi: 10.31729/jnma.8340.
INTRODUCTION
About 424.9 million people worldwide are affected by Diabetes mellitus. Prevalence among people 20-79 years old in Nepal was 4% in 2017. It is associated with microvascular and macrovascular complications such as peripheral neuropathy leading to risk of foot ulcers and amputation, and impaired sensation in their feet. The study aimed to find the prevalence of vitamin B12 deficiency among metformin-treated type 2 diabetic patients visiting the Department of Medicine of a tertiary care centre.
METHODS
A descriptive cross-sectional study was conducted in a tertiary care centre between 24 May 2021 to 24 May 2022 after obtaining ethical approval from the Institutional Review Committee. Patients who visited the Department of Medicine and gave informed consent were included in the study. Patients with underlying comorbidities were excluded from the study. A convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval.
RESULTS
Among 330 patients, vitamin B12 deficiency was seen in 33 (10%) (6.76-13.24, 95% Confidence Interval). Among them, 27 (81.82%) were male and 6 (18.18%) were female.
CONCLUSIONS
The prevalence of vitamin B12 deficiency was found to be higher than other studies done in similar settings.
KEYWORDS
diabetic neuropathy; metformin; type 2 diabetes; vitamin B12.
简介
全球约有 4.249 亿人患有糖尿病。2017 年，尼泊尔 20-79 岁人群的患病率为 4%。它与微血管和大血管并发症有关，如导致足部溃疡和截肢风险的周围神经病变，以及足部感觉受损。本研究旨在发现接受二甲双胍治疗的 2 型糖尿病患者中维生素 B12 缺乏的患病率，该研究在获得机构审查委员会的伦理批准后，于 2021 年 5 月 24 日至 2022 年 5 月 24 日在一家三级保健中心进行。
方法
这是一项在三级保健中心进行的描述性横断面研究。在获得机构审查委员会的伦理批准后，于 2021 年 5 月 24 日至 2022 年 5 月 24 日在该中心进行。纳入了访问内科并签署知情同意书的患者。患有潜在合并症的患者被排除在研究之外。采用方便抽样法。点估计值是在 95%置信区间计算的。
结果
在 330 名患者中，有 33 名（10%）（6.76-13.24，95%置信区间）存在维生素 B12 缺乏。其中，27 名（81.82%）为男性，6 名（18.18%）为女性。
结论
与在类似环境中进行的其他研究相比，发现维生素 B12 缺乏的患病率更高。
关键词
糖尿病神经病变；二甲双胍；2 型糖尿病；维生素 B12。
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