Zhao Jiaqi, Liu Fangxiao, Bai Lingshuo, Jiao Zheng, Meng Zihui, Jia Bo, Huang Yu, Liu Lin
Department of Gastroenterology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Liaoning University of Traditional Chinese Medicine, Shenyang, China.
J Transl Autoimmun. 2023 Dec 20;8:100225. doi: 10.1016/j.jtauto.2023.100225. eCollection 2024 Jun.
Patients with ulcerative colitis (UC) often exhibit susceptibilities to multiple autoimmune diseases such as Sjogren's syndrome, primary sclerosing cholangitis, systemic lupus erythematosus, and insulin-dependent diabetes mellitus. This propensity likely stems from common pathogenic mechanisms underlying immune-mediated conditions. This report highlights the occurrence of autoimmune thyroid disease during UC exacerbations. Notably, the patient displayed petrified auricles.Case Summary.A 57-year-old male complained of sustained abdominal pain, diarrhea, hematochezia, and mucus for a duration of 20 days. The diagnosis of UC was confirmed via colonoscopy, histopathological examination, and small bowel MRE. Clinical evaluations revealed bilateral ectopic ossification in his ears, which appeared to develop over an unspecified timeframe. Imaging and histological evaluations substantiated the ectopic ossification diagnosis while eliminating the possibility of adrenal insufficiency. The presented case offers a unique instance of bilateral auricular ossification, which is hypothesized to result from hyperthyroidism.
Our case report underscores the necessity of enhancing awareness of the rare complications associated with UC. Medical practitioners should recognize the potential overlap of autoimmune thyroid disorders in UC patients. It is imperative to test for thyroid-related antibodies in such individuals, irrespective of overt thyroid dysfunction.
溃疡性结肠炎(UC)患者常易患多种自身免疫性疾病,如干燥综合征、原发性硬化性胆管炎、系统性红斑狼疮和胰岛素依赖型糖尿病。这种倾向可能源于免疫介导疾病的共同致病机制。本报告强调了UC病情加重期间自身免疫性甲状腺疾病的发生。值得注意的是,该患者出现了耳廓石化。
病例摘要。一名57岁男性主诉持续腹痛、腹泻、便血和黏液便20天。通过结肠镜检查、组织病理学检查和小肠磁共振肠造影确诊为UC。临床评估发现其双耳存在双侧异位骨化,其似乎在未明确的时间段内形成。影像学和组织学评估证实了异位骨化的诊断,同时排除了肾上腺功能不全的可能性。该病例呈现了双侧耳廓骨化的独特实例,据推测这是由甲状腺功能亢进引起的。
我们的病例报告强调了提高对UC相关罕见并发症认识的必要性。医生应认识到UC患者中自身免疫性甲状腺疾病的潜在重叠。对于此类患者,无论是否存在明显的甲状腺功能障碍,都必须检测甲状腺相关抗体。