薰衣草油和杂薰衣草油对丝状真菌的多因素作用。
Multifactorial action of lavender and lavandin oils against filamentous fungi.
作者信息
Donadu Matthew Gavino, Ferrari Marco, Behzadi Payam, Trong Le Nhan, Usai Donatella, Fiamma Maura, Battah Basem, Barac Aleksandra, Bellardi Maria Grazia, Hoai Thi Nguyen, Mazzarello Vittorio, Rubino Salvatore, Cappuccinelli Piero, Zanetti Stefania
机构信息
Department of Biomedical Science, University of Sassari, Sassari, Italy.
Hospital Pharmacy, Giovanni Paolo II Hospital, ASL Gallura, Olbia, Italy.
出版信息
Nat Prod Res. 2025 Mar;39(6):1520-1528. doi: 10.1080/14786419.2024.2301741. Epub 2024 Jan 31.
AIMS
In this study, five essential oils (EOs) from different species of , for R.C., 'super A', 'super Z' and and its hybrids Lavender were evaluated against 26 dust-isolated fungal strains from North Africa.
METHODS AND RESULTS
The composition of the different EOs was determined from volume to dry weight. The photochemical analyses were performed gas chromatography (GC). The cytotoxic effect of five lavender EOs on human epithelial colorectal adenocarcinoma cells (Caco-2) cell line was done. A total of 26 strains of filamentous fungi including , , , and were isolated from sand dust samples molecular diagnostic tool of PCR. Fungal strains with the lowest minimal lethal concentration (MLC) were spp. and a strain of spp.
CONCLUSIONS
More studies are needed to verify the activity of this EO against more different fungal species, and determine the active ingredients. MIC of the antifungal efficacy relating to EOs was evaluated. The EOs tests showed no cytotoxic effect at very low concentrations, ranging from 0.03% (IC 0.9132 mg/mL) ( Abrialis) to 0.001% (IC 1.631 mg/mL) ( R.C.).
目的
在本研究中，对来自不同物种的五种精油（EOs）进行了评估，这些精油分别来自R.C.、“超级A”、“超级Z”以及薰衣草及其杂交品种，用于对抗从北非分离出的26株灰尘中的真菌菌株。
方法与结果
从体积到干重测定了不同精油的成分。通过气相色谱（GC）进行光化学分析。对五种薰衣草精油对人上皮性结肠腺癌（Caco - 2）细胞系的细胞毒性作用进行了研究。使用聚合酶链反应（PCR）分子诊断工具，从沙尘样本中总共分离出26株丝状真菌，包括曲霉属、青霉属、镰刀菌属、毛霉属和根霉属。最低致死浓度（MLC）最低的真菌菌株是曲霉属的一些种和一株镰刀菌属的菌株。
结论
需要更多研究来验证这种精油对更多不同真菌物种的活性，并确定其活性成分。评估了与精油相关的抗真菌功效的最低抑菌浓度（MIC）。精油测试表明，在非常低的浓度下没有细胞毒性作用，浓度范围从0.03%（IC 0.9132 mg/mL）（阿氏曲霉）到0.001%（IC 1.631 mg/mL）（R.C.）。
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