Department of Anesthesiology and Critical Care, Reims University Hospital, Hôpital Robert Debré - CHU de Reims, Rue Koenig, Reims F-51100, France.
Department of Bacteriology, Reims University Hospital, Reims F-51100, France.
Diagn Microbiol Infect Dis. 2024 Apr;108(4):116202. doi: 10.1016/j.diagmicrobio.2024.116202. Epub 2024 Feb 1.
Gardnerella vaginalis (G. vaginalis) is a bacterium rarely responsible for systemic infections and is exceptionally isolated from bronchopulmonary samples. Here, we report here two patients with trauma who were diagnosed with a G. vaginalis ventilatory acquired pneumonia (VAP) via mini bronchoalveolar lavage (mini-BAL). According to our observations, G. vaginalis was the only microorganism with a significant threshold and the identification was obtained by a reliable mean. There is no recommendation for antibiotic treatment for invasive G. vaginalis infection. We treated these infections with Cefotaxim and Metronidazole which clinically improved the infection. To determine whether the two patients were infected by the same strain, we used a random amplified polymorphic DNA (RAPD) technique. The two G. vaginalis organisms had distinct RAPD profiles, suggesting the absence of cross-transmission. These two cases of trauma and G. vaginalis VAP suggest that this infection cannot be ruled out and should alert the clinician to treat it.
阴道加德纳菌(G. vaginalis)很少引起全身感染,且极难从支气管肺样本中分离出来。在这里,我们报告了两名创伤患者,他们通过迷你支气管肺泡灌洗(mini-BAL)被诊断为阴道加德纳菌呼吸机相关性肺炎(VAP)。根据我们的观察,阴道加德纳菌是唯一具有显著阈值的微生物,并且通过可靠的方法进行了鉴定。对于侵袭性阴道加德纳菌感染,没有抗生素治疗的建议。我们用头孢噻肟和甲硝唑治疗这些感染,临床症状改善了感染。为了确定这两名患者是否被同一菌株感染,我们使用了随机扩增多态性 DNA(RAPD)技术。这两个阴道加德纳菌的 RAPD 图谱不同,提示不存在交叉传播。这两例创伤和阴道加德纳菌 VAP 表明,不能排除这种感染的可能性,临床医生应注意治疗。