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Arexvy:呼吸道合胞病毒疫苗的全面综述——革命性的保护。

Arexvy: A Comprehensive Review of the Respiratory Syncytial Virus Vaccine for Revolutionary Protection.

机构信息

Department of Pharmacy Practice, Bapuji Pharmacy College, Rajiv Gandhi University of Health Sciences, Davangere, Karnataka, India.

出版信息

Viral Immunol. 2024 Jan-Feb;37(1):12-15. doi: 10.1089/vim.2023.0093. Epub 2024 Feb 5.

Abstract

The respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in children and poses a significant risk to older adults. Developing a vaccine against RSV has been a priority, and the recently approved Arexvy vaccine has shown promise in preventing lower respiratory tract disease (LRTD) caused by RSV in individuals aged 60 years and older. This comprehensive review discusses the history of RSV, challenges in vaccine development, and the mechanism of action of Arexvy. The efficacy and safety of the vaccine are explored based on phase 3 clinical trial, demonstrating its effectiveness in preventing RSV-associated LRTD. The most common adverse reactions reported include injection site pain, fatigue, myalgia, headache, and arthralgia. Ongoing research focuses on the long-term effectiveness of Arexvy, including the need for booster doses and its impact on reducing RSV-associated hospitalizations. The potential of Arexvy to lessen the burden of RSV-related illnesses, particularly in vulnerable populations, is highlighted, emphasizing the importance of widespread immunization efforts and accessibility to this groundbreaking vaccine.

摘要

呼吸道合胞病毒(RSV)是导致儿童急性下呼吸道感染的主要原因,也是老年人的重大健康威胁。开发 RSV 疫苗一直是重中之重,最近批准的 Arexvy 疫苗在预防 60 岁及以上人群由 RSV 引起的下呼吸道疾病(LRTD)方面显示出良好的效果。本综述讨论了 RSV 的历史、疫苗开发的挑战以及 Arexvy 的作用机制。基于 3 期临床试验,探讨了疫苗的疗效和安全性,证实了其预防 RSV 相关 LRTD 的有效性。报告的最常见不良反应包括注射部位疼痛、疲劳、肌痛、头痛和关节痛。正在进行的研究集中在 Arexvy 的长期效果上,包括需要加强剂量以及其对减少 RSV 相关住院的影响。强调了 Arexvy 减轻与 RSV 相关疾病负担的潜力,特别是在脆弱人群中,突出了广泛免疫接种努力和获得这种突破性疫苗的重要性。

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