数据和安全监测委员会：临床试验中最艰巨的工作。
The Data and Safety Monitoring Board: The Toughest Job in Clinical Trials.
机构信息
Biostatistics Center, Milken Institute School of Public Health, George Washington University, Rockville, MD.
出版信息
NEJM Evid. 2023 Feb;2(2):EVIDctw2200220. doi: 10.1056/EVIDctw2200220. Epub 2023 Jan 24.
The DSMB: The Toughest Job in Clinical TrialsIn this review article, the authors discuss methods that DSMBs can use to compare the absolute and relative risks of benefits and adverse effects between trial interventions and illustrate how the DSMB can use this approach to evaluate the balance of these competing risks. Two approaches are discussed - the win ratio and the DOOR probability on one treatment relative to another.
《DSMB：临床试验中最艰巨的工作》
在这篇综述文章中，作者讨论了 DSMB 可以用来比较试验干预措施的获益和不良事件的绝对风险和相对风险的方法，并说明了 DSMB 如何使用这种方法来评估这些相互竞争的风险的平衡。讨论了两种方法 - 一种是治疗方法的胜率，另一种是治疗方法的 DOOR 概率。
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