环状 RNA 及其在特发性肺纤维化中的作用。
Circular RNAs and their roles in idiopathic pulmonary fibrosis.
机构信息
The Lundberg-Kienlen Lung Biology and Toxicology Laboratory, Department of Physiological Sciences, Oklahoma State University, 264 McElroy Hall, Stillwater, OK, 74078, USA.
Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, Oklahoma, USA.
出版信息
Respir Res. 2024 Feb 6;25(1):77. doi: 10.1186/s12931-024-02716-2.
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited treatment options. Circular RNAs (circRNAs) have emerged as a novel class of non-coding RNAs with diverse functions in cellular processes. This review paper aims to explore the potential involvement of circRNAs in the pathogenesis of IPF and their diagnostic and therapeutic implications. We begin by providing an overview of the epidemiology and risk factors associated with IPF, followed by a discussion of the pathophysiology underlying this complex disease. Subsequently, we delve into the history, types, biogenesis, and functions of circRNAs and then emphasize their regulatory roles in the pathogenesis of IPF. Furthermore, we examine the current methodologies for detecting circRNAs and explore their diagnostic applications in IPF. Finally, we discuss the potential utility of circRNAs in the treatment of IPF. In conclusion, circRNAs hold great promise as novel biomarkers and therapeutic targets in the management of IPF.
特发性肺纤维化（IPF）是一种进行性和致命性的肺部疾病，治疗选择有限。环状 RNA（circRNA）作为一类新型非编码 RNA，在细胞过程中具有多种功能。这篇综述论文旨在探讨 circRNA 在 IPF 发病机制中的潜在作用及其在诊断和治疗方面的意义。我们首先提供与 IPF 相关的流行病学和风险因素概述，接着讨论该复杂疾病的病理生理学基础。随后，我们深入探讨 circRNA 的历史、类型、生物发生和功能，并强调它们在 IPF 发病机制中的调节作用。此外，我们还研究了检测 circRNA 的当前方法，并探讨了它们在 IPF 诊断中的应用。最后，我们讨论了 circRNA 在 IPF 治疗中的潜在应用。总之，circRNA 作为新型生物标志物和治疗靶点，在 IPF 的管理中具有很大的应用前景。
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