Department of Nutrition and Dietetics, Bandirma Onyedi Eylul University, Balikesir, Turkey.
Department of Nutrition and Dietetics, Gazi University, Ankara, Turkey.
Curr Nutr Rep. 2024 Jun;13(2):69-81. doi: 10.1007/s13668-024-00520-4. Epub 2024 Feb 8.
As research on the potential impact of nutrition on mental disorders, a significant component of global disability continues to grow the concepts of "nutritional psychiatry, psycho-dietetics/nutripsychiatry" have taken their place in the literature. This review is a comprehensive examination of the literature on the the potential mechanisms between common mental disorders and nutrition and evaluates the effectiveness of dietary interventions.
Inflammation, oxidative stress, intestinal microbiota, mitochondrial dysfunction, and neural plasticity are shown as potential mechanisms in the relationship between mental disorders and nutrition. As a matter of fact, neurotrophic factors, which make important contributions to repair mechanisms throughout life, and neuronal plasticity, which plays a role in mental disorders, are affected by nutritional factors. In metabolism, the antioxidant defense system works with nutritional cofactors and phytochemicals. A balanced, planned diet that provides these components is more likely to provide nutrients that increase resilience against the pathogenesis of mental disorders. Nutrition can be considered a risk factor for mental disorders. Therefore, developing public health strategies focused on improving diet may help reduce the global burden of mental disorders and other related diseases.
随着营养对精神障碍潜在影响的研究不断深入,精神障碍已成为全球残疾的一个重要组成部分,“营养精神病学、心理营养学/营养精神病学”的概念在文献中也占据了一席之地。本综述全面考察了常见精神障碍与营养之间的潜在机制,并评估了饮食干预的效果。
炎症、氧化应激、肠道微生物群、线粒体功能障碍和神经可塑性被认为是精神障碍与营养之间关系的潜在机制。事实上,神经营养因子对终生修复机制有重要贡献,神经元可塑性在精神障碍中起作用,它们都受到营养因素的影响。在代谢中,抗氧化防御系统与营养辅助因子和植物化学物质一起发挥作用。均衡、有计划的饮食提供这些成分,更有可能提供增加对精神障碍发病机制抵抗力的营养物质。营养可以被视为精神障碍的一个风险因素。因此,制定注重改善饮食的公共卫生策略可能有助于减轻全球精神障碍和其他相关疾病的负担。