磁共振 T1rho 和 T2 映射在评估中老年膝骨关节炎患者软骨损伤中的应用。
Application of Magnetic Resonance T1rho and T2 Mapping in Evaluating Cartilage Injury in Middle-aged and Elderly Patients with Knee Osteoarthritis.
作者信息
Tang Li, Gao Yanfang, Deng Chengzhe, Gong Yurong
出版信息
Altern Ther Health Med. 2024 Oct;30(10):308-313.
OBJECTIVE
To investigate magnetic resonance longitudinal relaxation time quantitative imaging (T1rho) and transverse relaxation time quantitative imaging (T2 mapping) techniques in evaluating cartilage damage in middle-aged and elderly patients with knee osteoarthritis (OA).
METHODS
To carry out this investigation, the researchers enrolled 65 OA patients subjects for the study. These patients were divided into 2 groups based on the severity of their OA. Thirty healthy individuals were included as the control group. All study participants underwent magnetic resonance T1rho and T2 mapping scans. OA patient scores and values from the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), T2, and a T1rho MRI measurement indicating potential early indication of bone and joint diseases from each cartilage area were compared among the OA patients as well as the control group. Pearson correlation analysis was used to examine the relationships between T2 and T1rho values and WOMAC scores.
RESULTS
The WOMAC scores in the mild OA group were lower than the severe OA group (P < .05). There were no significant differences in T2 and T1rho values of lateral tibial cartilage among the 3 groups (P > .05). On the other hand, the T2 and T1rho values of medial femoral, lateral femoral, and medial tibial cartilage areas increased progressively in the control, mild OA, and severe OA groups (P < .05). A Pearson analysis found a positive correlation between the T2 values of medial, lateral, and medial tibial cartilages and the WOMAC scores. Similarly, the T1rho values of these cartilage areas were also positively correlated with the WOMAC scores.
CONCLUSION
Magnetic resonance T1rho and T2 mapping offer good evaluation value for assessing cartilage injury in middle-aged and elderly patients with knee OA. The values obtained from T1rho and T2 mapping in various areas of the cartilage show a positive correlation with WOMAC scores.
目的
探讨磁共振纵向弛豫时间定量成像（T1rho）和横向弛豫时间定量成像（T2 映射）技术在评估中老年膝骨关节炎（OA）患者软骨损伤中的作用。
方法
研究者纳入 65 例 OA 患者为研究对象，根据 OA 严重程度将患者分为 2 组，另选 30 例健康人作为对照组。所有研究对象均行膝关节磁共振 T1rho 和 T2 映射扫描，比较 OA 患者组及对照组各软骨区 OA 患者评分及 Western Ontario and McMaster University Osteoarthritis Index（WOMAC）评分、T2 值和 T1rho MRI 测量值，分析 T2 值和 T1rho 值与 WOMAC 评分的相关性。
结果
轻度 OA 组 WOMAC 评分低于重度 OA 组（P＜0.05），3 组间外侧胫骨软骨 T2 值和 T1rho 值差异均无统计学意义（P＞0.05），而内侧股骨、外侧股骨和内侧胫骨软骨 T2 值和 T1rho 值随对照组、轻度 OA 组和重度 OA 组逐渐升高（P＜0.05）。Pearson 分析发现内侧、外侧和内侧胫骨软骨 T2 值与 WOMAC 评分呈正相关，T1rho 值与 WOMAC 评分也呈正相关。
结论
磁共振 T1rho 和 T2 映射对评估中老年膝骨关节炎患者的软骨损伤具有良好的评价价值，软骨各部位 T1rho 和 T2 值与 WOMAC 评分呈正相关。
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