抗氧化剂对传统和先进精子功能参数的影响：最新综述。
Impact of Antioxidants on Conventional and Advanced Sperm Function Parameters: An Updated Review.
作者信息
Alharbi Mohannad
机构信息
Department of Urology, College of Medicine, Qassim University, Qassim, SAU.
出版信息
Cureus. 2024 Feb 15;16(2):e54253. doi: 10.7759/cureus.54253. eCollection 2024 Feb.
Abstract
Antioxidants include diverse exogenous and endogenous compounds that can neutralize free radical activity, which ultimately protects sperm from oxidative stress (OS). Nevertheless, a controlled balance between oxidation and reduction is of paramount importance for cellular function. Excessive use of antioxidants should be avoided. A combination of antioxidants has been utilized to obtain a synergetic effect in the treatment of male infertility. Antioxidants have been shown to have a positive effect on semen parameters with a decrease in DNA damage. Future large randomized controlled trials are needed to determine the real impact of antioxidants on semen parameters, reproductive outcomes, and DNA integrity.
摘要
抗氧化剂包括多种外源性和内源性化合物，它们能够中和自由基活性，最终保护精子免受氧化应激（OS）的影响。然而，氧化与还原之间的平衡对于细胞功能至关重要。应避免过度使用抗氧化剂。已采用抗氧化剂组合在治疗男性不育症中获得协同效应。抗氧化剂已被证明对精液参数有积极影响，并能减少DNA损伤。未来需要进行大规模随机对照试验，以确定抗氧化剂对精液参数、生殖结局和DNA完整性的实际影响。
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本文引用的文献
1
Impact of antioxidant treatment on DNA fragmentation index: a double-blind placebo-controlled randomized trial.
Andrology. 2018 Nov;6(6):811-816. doi: 10.1111/andr.12547. Epub 2018 Oct 8.
2
The excessive use of antioxidant therapy: A possible cause of male infertility?
Andrologia. 2019 Feb;51(1):e13162. doi: 10.1111/and.13162. Epub 2018 Sep 26.
3
Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: A double-blind placebo-controlled study.
Andrologia. 2018 Apr;50(3). doi: 10.1111/and.12927. Epub 2018 Jan 7.
4
Antioxidant supplements and semen parameters: An evidence based review.
Int J Reprod Biomed. 2016 Dec;14(12):729-736.
5
Oral Zinc Supplementation Restores Superoxide Radical Scavengers to Normal Levels in Spermatozoa of Iraqi Asthenospermic Patients.
Int J Vitam Nutr Res. 2015;85(3-4):165-73. doi: 10.1024/0300-9831/a000235.
6
Effect of Ubiquinol Therapy on Sperm Parameters and Serum Testosterone Levels in Oligoasthenozoospermic Infertile Men.
J Clin Diagn Res. 2015 Sep;9(9):BC01-3. doi: 10.7860/JCDR/2015/13617.6424. Epub 2015 Sep 1.
7
Combination of vitamin E and clomiphene citrate in treating patients with idiopathic oligoasthenozoospermia: A prospective, randomized trial.
Andrology. 2015 Sep;3(5):864-7. doi: 10.1111/andr.12086. Epub 2015 Jul 31.
8
Oral antioxidant treatment partly improves integrity of human sperm DNA in infertile grade I varicocele patients.
Hum Fertil (Camb). 2015 Sep;18(3):225-9. doi: 10.3109/14647273.2015.1050462. Epub 2015 Jun 19.
9
The effect of adjuvant vitamin C after varicocele surgery on sperm quality and quantity in infertile men: a double blind placebo controlled clinical trial.
Int Braz J Urol. 2015 Mar-Apr;41(2):230-8. doi: 10.1590/S1677-5538.IBJU.2015.02.07.
10
Antioxidants for male subfertility.
Cochrane Database Syst Rev. 2014(12):CD007411. doi: 10.1002/14651858.CD007411.pub3. Epub 2014 Dec 15.
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