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减肥对肥胖合并 2 型糖尿病患者肾功能的影响:综合评价。

The impact of weight loss on renal function in individuals with obesity and type 2 diabetes: a comprehensive review.

机构信息

Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China.

Division of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Front Endocrinol (Lausanne). 2024 Jan 31;15:1320627. doi: 10.3389/fendo.2024.1320627. eCollection 2024.

Abstract

Obesity and Type 2 Diabetes (T2D) are two highly prevalent diseases that exhibit a complex interplay between them. Obesity serves as a primary risk factor for the development of T2D, and conversely, individuals with T2D often exhibit comorbid obesity. Renal dysfunction emerges as a critical consequence of the convergence of obesity and Type 2 Diabetes, contributing significantly to the overall burden of complications associated with these conditions. Recognizing the profound implications of renal dysfunction in individuals contending with both obesity and Type 2 Diabetes, interventions targeting weight loss have gained prominence as potential therapeutic avenues. Weight loss not only addresses the primary risk factor of obesity but also holds the promise of mitigating the progression of Type 2 Diabetes and its associated renal complications. This comprehensive review aims to explore the impact of weight loss on renal function in individuals contending with the convergence of obesity and T2D.

摘要

肥胖症和 2 型糖尿病(T2D)是两种高发疾病,它们之间存在着复杂的相互作用。肥胖症是 T2D 发展的主要危险因素,反之,T2D 患者常常伴有肥胖症共病。肾功能障碍是肥胖症和 2 型糖尿病相互作用的一个关键后果,极大地增加了与这些疾病相关并发症的整体负担。鉴于肾功能障碍在肥胖症和 2 型糖尿病患者中的深远影响,针对体重减轻的干预措施已成为一种有前途的治疗途径。体重减轻不仅可以解决肥胖症的主要危险因素,还有望减缓 2 型糖尿病及其相关肾脏并发症的进展。本综述旨在探讨体重减轻对肥胖症和 T2D 患者肾脏功能的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/721f/10867247/3b6066a116bc/fendo-15-1320627-g001.jpg

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