Cai Jin, Zhou Xueming, Wang Bin, Zhang Xuelong, Luo Mengyao, Huang Longtao, Wang Ruoxi, Chen Yonghao, Li Xiaoyang, Luo Youping, Chen Guangying, Cao Fei, Huang Guolei, Zheng Caijuan
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, Hainan, China.
Front Microbiol. 2024 Feb 1;15:1342843. doi: 10.3389/fmicb.2024.1342843. eCollection 2024.
Six new polyketides, which includes three new lactones (talarotones A-C) , one new polyketide (talarotide A) , two new polyenes (talaroyenes A, B) , together with one new meroterpenoid (talaropenoid A) and 13 known compounds were isolated from the mangrove-derived fungus TGGP35. The structure and configuration of the compounds - were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo (OAc)-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds and displayed antioxidant activity with IC values of 0.40 and 1.36 mM, respectively. Compounds , , , , and displayed cytotoxic activity against human cancer cells Hela, A549, and had IC values ranging from 28.89 to 62.23 μM. Compounds , -, and - exhibited moderate or potent anti-insect activity against newly hatched larvae of Hubner, with IC values in the range 50-200 μg/mL. Compound showed antibacterial activity against with the MIC value of 50 μg/mL.
从源自红树林的真菌TGGP35中分离出6种新的聚酮化合物，其中包括3种新的内酯（塔拉罗酮A - C）、1种新的聚酮化合物（塔拉罗肽A）、2种新的多烯（塔拉罗烯A、B），以及1种新的半萜类化合物（塔拉罗培诺醇A）和13种已知化合物。通过高分辨电喷雾电离质谱（HR - ESI - MS）、红外光谱（IR）、一维/二维核磁共振波谱（1D/2D NMR）、钼（乙酸根）诱导的电子圆二色光谱（ECD）、圆二色光谱（CD）以及改良的莫舍尔方法所获得的数据，阐明了这些化合物的结构和构型。化合物 和 表现出抗氧化活性，其半数抑制浓度（IC）值分别为0.40和1.36 mM。化合物 、 、 、 和 对人类癌细胞Hela、A549表现出细胞毒性活性，IC值范围为28.89至62.23 μM。化合物 、 - 和 - 对新孵化的赫伯纳幼虫表现出中等或强效的抗昆虫活性，IC值在50 - 200 μg/mL范围内。化合物 对 表现出抗菌活性，最低抑菌浓度（MIC）值为50 μg/mL。
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