1st Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.
Department of Nephrology and Hypertension, University Hospital Erlangen, Germany.
Nephrol Dial Transplant. 2024 May 31;39(6):929-943. doi: 10.1093/ndt/gfae041.
In June 2023, the European Society of Hypertension (ESH) presented and published the new 2023 ESH Guidelines for the Management of Arterial Hypertension, a document that was endorsed by the European Renal Association (ERA). Following the evolution of evidence in recent years, several novel recommendations relevant to the management of hypertension in patients with chronic kidney disease (CKD) appeared in these Guidelines. These include recommendations for target office blood pressure (BP) <130/80 mmHg in most and against target office BP <120/70 mmHg in all patients with CKD; recommendations for use of spironolactone or chlorthalidone for patients with resistant hypertension with estimated glomerular filtration rate (eGFR) higher or lower than 30 mL/min/1.73 m2, respectively; use of a sodium-glucose cotransporter 2 inhibitor for patients with CKD and estimated eGFR ≥20 mL/min/1.73 m2; use of finerenone for patients with CKD, type 2 diabetes mellitus, albuminuria, eGFR ≥25 mL/min/1.73 m2 and serum potassium <5.0 mmol/L; and revascularization in patients with atherosclerotic renovascular disease and secondary hypertension or high-risk phenotypes if stenosis ≥70% is present. The present report is a synopsis of sections of the ESH Guidelines that are relevant to the daily clinical practice of nephrologists, prepared by experts from ESH and ERA. The sections summarized are those referring to the role of CKD in hypertension staging and cardiovascular risk stratification, the evaluation of hypertension-mediated kidney damage and the overall management of hypertension in patients with CKD.
2023 年 6 月,欧洲高血压学会(ESH)发布了新的 2023 年ESH 高血压管理指南,该指南得到了欧洲肾脏协会(ERA)的认可。近年来,随着证据的不断发展,这些指南中出现了一些与慢性肾脏病(CKD)患者高血压管理相关的新建议。这些建议包括:大多数患者的诊室血压(BP)目标<130/80mmHg,而所有 CKD 患者的诊室 BP 目标<120/70mmHg;对于估计肾小球滤过率(eGFR)高于或低于 30mL/min/1.73m2 的患者,分别建议使用螺内酯或氯噻酮治疗难治性高血压;对于 eGFR≥20mL/min/1.73m2 的 CKD 患者,建议使用钠-葡萄糖共转运蛋白 2 抑制剂;对于 eGFR≥25mL/min/1.73m2、血清钾<5.0mmol/L 且有蛋白尿的 CKD 患者,建议使用非奈利酮;对于存在动脉粥样硬化性肾血管疾病和继发性高血压或高危表型且狭窄≥70%的患者,建议进行血运重建。本报告是 ESH 和 ERA 专家编写的与肾病学家日常临床实践相关的 ESH 指南部分的摘要,总结了指南中与 CKD 在高血压分期和心血管风险分层中的作用、高血压引起的肾脏损害的评估以及 CKD 患者的整体高血压管理相关的部分。