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胆囊切除术中发现的小胆管结石的处理。

Management of intraoperatively identified small bile duct stones in patients undergoing cholecystectomy.

机构信息

Department of Upper GI and Abdominal Wall Surgery, North Devon District Hospital, Barnstaple, Devon, EX31 4JB, UK.

University of Exeter Medical School, Exeter, EX1 2HZ, UK.

出版信息

Langenbecks Arch Surg. 2024 Feb 22;409(1):70. doi: 10.1007/s00423-024-03260-9.

Abstract

INTRODUCTION

The management of CBDS (common bile duct stones) in patients with co-existing gallbladder stones has been debated. Guidelines recommend patients with CBDS identified on imaging should be offered duct clearance; however, this is based on low-quality evidence. This study aimed to investigate the natural history of small CBDS identified using IOUS (intraoperative ultrasound) in patients undergoing cholecystectomy. This may provide evidence to support a short-term expectant management approach in such patients.

METHODS

Patients with CBDS diagnosed on IOUS during cholecystectomy were identified from a database of consecutive patients undergoing surgery. Patients with CBDS identified were divided into small stone (SS, ≤5 mm) and large stone (LS, >5 mm) groups. Intraoperative CBDS management, postoperative investigations, postoperative bile duct clearance, re-admissions, complications, length of stay (LOS) and follow-up are described.

RESULTS

Fifty-nine of 427 patients had CBDS identified on IOUS. In the SS group (n=51), 46 patients underwent short-term expectant management rather than immediate/planned bile duct clearance. Following short-term expectant management, 41/46 patients (89.1%) did not require postoperative endoscopic retrograde cholangiopancreatography and at >3 year follow-up, none has since presented with residual CBDS. Median LOS was 0 days in the short-term expectant management group and 2 days in the immediate/planned bile duct clearance group, P=0.039.

CONCLUSIONS

This study reports the natural history of small CBDS identified on IOUS in patients undergoing cholecystectomy. Such patients were safely treated with short-term expectant management associated with a reduced hospital LOS. This provides rationale for undertaking further research to establish this as a preferred management strategy.

摘要

简介

在同时患有胆囊结石的患者中,CBDS(胆总管结石)的治疗方法一直存在争议。指南建议对影像学检查发现 CBDS 的患者进行胆管清除术;然而,这一建议的证据质量较低。本研究旨在探讨在接受胆囊切除术的患者中,使用 IOUS(术中超声)发现的小 CBDS 的自然病程。这可能为支持此类患者采用短期期待治疗方法提供依据。

方法

从接受手术的连续患者数据库中确定在胆囊切除术中通过 IOUS 诊断出 CBDS 的患者。将 CBDS 患者分为小结石(SS,≤5mm)和大结石(LS,>5mm)组。描述术中 CBDS 处理、术后检查、术后胆管清除术、再入院、并发症、住院时间(LOS)和随访。

结果

427 例患者中有 59 例在 IOUS 上发现 CBDS。在 SS 组(n=51)中,46 例患者接受了短期期待治疗,而不是立即/计划进行胆管清除术。在短期期待治疗后,41/46 例患者(89.1%)无需进行术后内镜逆行胰胆管造影术,且在 >3 年的随访中,无患者出现残留 CBDS。在短期期待治疗组的中位 LOS 为 0 天,而在立即/计划胆管清除术组为 2 天,P=0.039。

结论

本研究报告了在接受胆囊切除术的患者中,通过 IOUS 发现的小 CBDS 的自然病程。对这些患者采用短期期待治疗是安全的,与降低住院 LOS 相关。这为进一步研究确立这种方法作为首选治疗策略提供了依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9a1/10884054/2e8c52e0b60d/423_2024_3260_Fig1_HTML.jpg

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