Division of Nephrology, University Hospital, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany.
Division of Experimental Medicine & Immunotherapeutics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Kidney Int. 2024 Mar;105(3):447-449. doi: 10.1016/j.kint.2023.10.009.
In 2021, the Kidney Disease: Improving Global Outcomes (KDIGO) Guideline for the Management of Glomerular Diseases was published. KDIGO is committed to providing the nephrology community with periodic updates, based on new developments for each disease. For patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), avacopan received regulatory approval in late 2021, leading to this KDIGO guideline update. In addition, the evidence supporting a lower-dose glucocorticoid induction regimen or even complete replacement of glucocorticoids has become stronger. Herein, an executive summary of the most important guideline changes from the AAV chapter is provided as a quick reference.
2021 年,《改善全球肾脏病预后组织(KDIGO)肾小球疾病管理指南》发布。KDIGO 致力于根据每种疾病的新进展,为肾脏病学社区提供定期更新。对于抗中性粒细胞胞浆抗体(ANCA)相关性血管炎(AAV)患者,avatrombopag 于 2021 年末获得监管批准,促成了本次 KDIGO 指南更新。此外,支持低剂量糖皮质激素诱导方案甚至完全替代糖皮质激素的证据也越来越充分。本文提供了 AAV 章节中最重要的指南更改的执行摘要,以供快速参考。