Comparison of Diagnostic Value between Technetium-Methylene Diphosphate Bone Scan and Technetium-Prostate-specific Membrane Antigen Scan in Patients with Prostate Cancer with Osseous Metastases.

BACKGROUND

Prostate cancer (PCa) ranks as the second most prevalent cancer among men globally. The utilization of efficient and cost-effective diagnostic and therapeutic approaches holds paramount importance in the diagnosis and treatment of these patients, significantly impacting treatment outcomes. This study focuses on the investigation and comparison of two commonly employed scans within the treatment process for these patients.

METHODS

In this prospective study, which spanned over 2 years, 40 patients diagnosed with PCa underwent examination using two scans: Technetium-Prostate-specific Membrane Antigen (TC-PSMA) Scan and between Technetium-Methylene Diphosphate (TC-MDP) Bone Scan. The findings of these scans were then compared with each other, as well as with the results obtained from magnetic resonance imaging and the prostate-specific antigen level. The analysis of the results was conducted utilizing SPSS 22 software, and descriptive statistical methods were employed to present the findings.

RESULTS

In this prospective study, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the TC-MDP Bone Scan were found to be 88.2%, 83.3%, 96.7%, 55.5%, and 87.5%, respectively. Similarly, for the TC-PSMA Scan, the corresponding values were 94.1%, 83.3%, 96.4%, 83.3%, and 92.5%, respectively.

CONCLUSIONS

Based on the findings of this study, it can be concluded that the diagnostic accuracy of the TC-PSMA Scan is marginally higher compared to the TC-MDP Bone Scan. Therefore, for patients who are limited to only one scan, the TC-PSMA Scan appears to be the preferable choice.