Yuan Yixuan, Tyson Caleb, Szyniec Annika, Agro Samuel, Tavakol Tara N, Harmon Alexander, Lampkins DessaRae, Pearson Lauran, Dumas Jerald E, Taite Lakeshia J
Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22903, USA.
Department of Chemical Engineering, Hampton University, Hampton, VA 23668, USA.
Gels. 2024 Jan 29;10(2):108. doi: 10.3390/gels10020108.
Polyurethanes (PUs) are a highly adaptable class of biomaterials that are among some of the most researched materials for various biomedical applications. However, engineered tissue scaffolds composed of PU have not found their way into clinical application, mainly due to the difficulty of balancing the control of material properties with the desired cellular response. A simple method for the synthesis of tunable bioactive poly(ethylene glycol) diacrylate (PEGDA) hydrogels containing photocurable PU is described. These hydrogels may be modified with PEGylated peptides or proteins to impart variable biological functions, and the mechanical properties of the hydrogels can be tuned based on the ratios of PU and PEGDA. Studies with human cells revealed that PU-PEG blended hydrogels support cell adhesion and viability when cell adhesion peptides are crosslinked within the hydrogel matrix. These hydrogels represent a unique and highly tailorable system for synthesizing PU-based synthetic extracellular matrices for tissue engineering applications.
聚氨酯（PU）是一类适应性很强的生物材料，是各种生物医学应用中研究最多的材料之一。然而，由PU组成的工程组织支架尚未进入临床应用，主要是因为难以在控制材料特性与期望的细胞反应之间取得平衡。本文描述了一种合成含有光固化PU的可调谐生物活性聚（乙二醇）二丙烯酸酯（PEGDA）水凝胶的简单方法。这些水凝胶可以用聚乙二醇化肽或蛋白质进行修饰，以赋予可变的生物学功能，并且水凝胶的机械性能可以根据PU和PEGDA的比例进行调节。对人类细胞的研究表明，当细胞粘附肽在水凝胶基质中交联时，PU-PEG混合水凝胶支持细胞粘附和活力。这些水凝胶代表了一种独特且高度可定制的系统，用于合成用于组织工程应用的基于PU的合成细胞外基质。
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