Lupia Carmine, Castagna Fabio, Bava Roberto, Naturale Maria Diana, Zicarelli Ludovica, Marrelli Mariangela, Statti Giancarlo, Tilocca Bruno, Roncada Paola, Britti Domenico, Palma Ernesto
Mediterranean Ethnobotanical Conservatory, Sersale (CZ), 88054 Catanzaro, Italy.
National Ethnobotanical Conservatory, Castelluccio Superiore, 85040 Potenza, Italy.
Antibiotics (Basel). 2024 Feb 7;13(2):163. doi: 10.3390/antibiotics13020163.
Antimicrobial resistance is an increasingly widespread phenomenon that is of particular concern because of the possible consequences in the years to come. The dynamics leading to the resistance of microbial strains are diverse, but certainly include the incorrect use of veterinary drugs both in terms of dosage and timing of administration. Moreover, the drug is often administered in the absence of a diagnosis. Many active ingredients in pharmaceutical formulations are, therefore, losing their efficacy. In this situation, it is imperative to seek alternative treatment solutions. Essential oils are mixtures of compounds with different pharmacological properties. They have been shown to possess the antibacterial, anti-parasitic, antiviral, and regulatory properties of numerous metabolic processes. The abundance of molecules they contain makes it difficult for treated microbial species to develop pharmacological resistance. Given their natural origin, they are environmentally friendly and show little or no toxicity to higher animals. There are several published studies on the use of essential oils as antimicrobials, but the present literature has not been adequately summarized in a manuscript. This review aims to shed light on the results achieved by the scientific community regarding the use of essential oils to treat the main agents of bacterial infection of veterinary interest in livestock. The Google Scholar, PubMed, SciELO, and SCOPUS databases were used for the search and selection of studies. The manuscript aims to lay the foundations for a new strategy of veterinary drug use that is more environmentally friendly and less prone to the emergence of drug resistance phenomena.
抗菌耐药性是一种日益普遍的现象,由于其在未来几年可能产生的后果,这一现象尤其令人担忧。导致微生物菌株产生耐药性的动态过程多种多样,但肯定包括兽药在剂量和给药时间方面的不当使用。此外,药物往往在未确诊的情况下就被使用。因此,许多药物制剂中的活性成分正在失去其效力。在这种情况下,寻求替代治疗方案势在必行。精油是具有不同药理特性的化合物的混合物。它们已被证明具有抗菌、抗寄生虫、抗病毒以及调节众多代谢过程的特性。它们所含分子的丰富性使得被治疗的微生物物种难以产生药理耐药性。鉴于其天然来源,它们对环境友好,对高等动物几乎没有毒性或完全没有毒性。关于使用精油作为抗菌剂已有多项已发表的研究,但目前的文献尚未在一篇手稿中得到充分总结。本综述旨在阐明科学界在使用精油治疗家畜中具有兽医意义的主要细菌感染病原体方面所取得的成果。使用谷歌学术、PubMed、SciELO和SCOPUS数据库进行研究的检索和筛选。该手稿旨在为一种更环保且更不易出现耐药现象的兽药使用新策略奠定基础。