Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Siriraj Center of Research Excellence for Diabetes and Obesity, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Int J Mol Sci. 2024 Feb 7;25(4):2039. doi: 10.3390/ijms25042039.
Gestational diabetes mellitus (GDM) is a significant pregnancy complication linked to perinatal complications and an elevated risk of future metabolic disorders for both mothers and their children. GDM is diagnosed when women without prior diabetes develop chronic hyperglycemia due to β-cell dysfunction during gestation. Global research focuses on the association between GDM and single nucleotide polymorphisms (SNPs) and aims to enhance our understanding of GDM's pathogenesis, predict its risk, and guide patient management. This review offers a summary of various SNPs linked to a heightened risk of GDM and explores their biological mechanisms within the tissues implicated in the development of the condition.
妊娠期糖尿病（GDM）是一种严重的妊娠并发症，与围产期并发症以及母亲及其子女未来代谢紊乱的风险增加有关。当没有先前糖尿病的女性由于β细胞功能障碍在妊娠期出现慢性高血糖时，就会诊断出 GDM。全球研究的重点是 GDM 与单核苷酸多态性（SNP）之间的关联，旨在增强我们对 GDM 发病机制的理解，预测其风险，并指导患者管理。这篇综述总结了与 GDM 风险增加相关的各种 SNP，并探讨了它们在与该疾病发展相关的组织中所涉及的生物学机制。
Zotero 插件