Department of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Biomolecules. 2024 Feb 4;14(2):191. doi: 10.3390/biom14020191.
We review emerging preclinical and clinical evidence regarding brain-derived neurotrophic factor (BDNF) protein, genotype, and DNA methylation (DNAm) as biomarkers of outcomes in three important etiologies of pediatric acquired brain injury (ABI), traumatic brain injury, global cerebral ischemia, and stroke. We also summarize evidence suggesting that BDNF is (1) involved in the biological embedding of the psychosocial environment, (2) responsive to rehabilitative therapies, and (3) potentially modifiable. BDNF's unique potential as a biomarker of neuroplasticity and neural repair that is reflective of and responsive to both pre- and post-injury environmental influences separates it from traditional protein biomarkers of structural brain injury with exciting potential to advance pediatric ABI management by increasing the accuracy of prognostic tools and informing clinical decision making through the monitoring of therapeutic effects.
我们回顾了有关脑源性神经营养因子（BDNF）蛋白、基因型和 DNA 甲基化（DNAm）作为三种重要儿科获得性脑损伤（ABI）的结局生物标志物的新兴临床前和临床证据，外伤性脑损伤、全脑缺血和中风。我们还总结了证据表明 BDNF 是：（1）参与心理社会环境的生物学嵌入；（2）对康复治疗有反应；（3）具有潜在的可修饰性。BDNF 作为神经可塑性和神经修复的生物标志物具有独特的潜力，它反映并响应损伤前后环境的影响，使其有别于传统的结构性脑损伤蛋白生物标志物，通过提高预后工具的准确性并通过监测治疗效果来告知临床决策，从而为儿科 ABI 管理提供了令人兴奋的潜在优势。
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