广谱护卫者：γδ T 细胞应对多种免疫挑战。
Broad-spectrum defenders: γδ T cells take on a multitude of immune challenges.
机构信息
Immunomonitoring Services, R&D, Sanquin Diagnostic Services, Plesmanlaan 125, 1066CX, Amsterdam, the Netherlands.
出版信息
J Leukoc Biol. 2024 Apr 29;115(5):794-796. doi: 10.1093/jleuko/qiae044.
A recent article in Proceedings of the National Academy of Sciences investigated γδ T cell antigen specificity in mice and humans, in which the authors show that γδ T cell antigen specificity is not constrained to one epitope. Rather, γδ T cells recognize a broad range of diverse antigens containing similar chemical structures or properties. In this News and Views, the importance of γδ T cell antigen polyspecificity during immune responses is highlighted.
最近发表在《美国国家科学院院刊》上的一篇文章研究了γδ T 细胞在小鼠和人类中的抗原特异性，作者表明γδ T 细胞的抗原特异性不受限于一个表位。相反，γδ T 细胞识别含有相似化学结构或性质的广泛多样的抗原。在这篇新闻和观点中，强调了免疫反应中 γδ T 细胞抗原多特异性的重要性。
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