肥胖表型对体重和体重指数的累积效应。
Cumulative effect of obesity phenotypes on body weight and body mass index.
机构信息
Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, Jacksonville, FL, USA.
出版信息
Int J Obes (Lond). 2024 Jun;48(6):884-890. doi: 10.1038/s41366-024-01492-9. Epub 2024 Feb 28.
BACKGROUND
Obesity originates from an imbalance between energy intake and expenditure. Changes in energy intake components (satiation, postprandial satiety, emotional eating) and energy expenditure have been linked to obesity and are referred to as obesity phenotypes. We aim to study if these obesity phenotypes have a cumulative effect on body weight and body mass index (BMI).
SUBJECT/METHODS: This is a cross-sectional study of adult patients with obesity (BMI > 30 kg/m) who completed the validated tests to measure the obesity phenotypes. A total of 464 were included in this study.
INTERVENTIONS/METHODS: We defined higher calories to fullness during an ad libitum meal as abnormal satiation, accelerated time to half gastric emptying with scintigraphy as abnormal postprandial satiety, higher anxiety score on the Hospital Anxiety and Depression Scale as hedonic eating behavior, and decreased percentage of measured resting energy expenditure as abnormal energy expenditure. The primary analysis was done on the number of phenotypes ( ≤ 1 and ≥ 2) with body weight and BMI using an independent t-test.
RESULTS
Our cohort included 464 patients (mean [SD] age 42.0 [10.9] years, 79% females, weight 111.2 [22.9] kg, BMI 38.9 [7.0] kg/m). There were 294 patients who had ≤ 1 phenotype, and 170 patients with ≥ 2 phenotypes with no baseline demographical differences (i.e., age and sex). Having ≥ 2 phenotypes was associated with higher body weight (115 [25] kg vs. 109 [21] kg; p = 0.004), BMI (40 [8] kg/m vs. 38 [7] kg/m; p = 0.02) and waist (118 [15] cm vs. 115 [13] cm; p = 0.04) and hip (129 [14] cm vs. 125 [13] cm; p = 0.01) circumferences compared to ≤ 1 phenotype.
CONCLUSION
Obesity phenotypes are associated with an additive effect on the body weight and BMI. Patients who have multiple obesity phenotypes may require a more aggressive approach to enhance weight loss.
背景
肥胖源于能量摄入和消耗之间的失衡。能量摄入成分（饱腹感、餐后饱腹感、情绪性进食）和能量消耗的变化与肥胖有关，被称为肥胖表型。我们旨在研究这些肥胖表型是否对体重和体重指数（BMI）有累积影响。
受试者/方法：这是一项横断面研究，纳入了肥胖（BMI>30kg/m）的成年患者，他们完成了测量肥胖表型的验证性测试。共有 464 名患者纳入本研究。
干预/方法：我们将自由进食期间摄入更多热量定义为异常饱腹感，闪烁扫描法检测到胃排空加速定义为异常餐后饱腹感，医院焦虑抑郁量表评分较高定义为享乐性进食行为，静息能量消耗测量值百分比降低定义为异常能量消耗。主要分析是基于表型数量（≤1 和≥2）与体重和 BMI 采用独立 t 检验。
结果
我们的队列纳入了 464 名患者（平均[标准差]年龄 42.0[10.9]岁，79%为女性，体重 111.2[22.9]kg，BMI 38.9[7.0]kg/m）。294 名患者有≤1 种表型，170 名患者有≥2 种表型，两组患者在基线人口统计学特征上无差异（即年龄和性别）。≥2 种表型与更高的体重（115[25]kg 与 109[21]kg；p=0.004）、BMI（40[8]kg/m 与 38[7]kg/m；p=0.02）和腰围（118[15]cm 与 115[13]cm；p=0.04）以及臀围（129[14]cm 与 125[13]cm；p=0.01）有关。
结论
肥胖表型与体重和 BMI 呈累加效应。有多种肥胖表型的患者可能需要更积极的方法来增强减肥效果。
Zotero 插件