Graduate School, Chengdu Medical College, Chengdu, China.
Department of Radiology, People's Hospital of Lushan County, Ya'an, China.
Pathol Oncol Res. 2024 Feb 21;30:1611595. doi: 10.3389/pore.2024.1611595. eCollection 2024.
Summarize the progress and hot topic evolution of non-coding RNAs (ncRNAs) research in esophageal squamous cell carcinoma (ESCC) in recent years and predict future research directions. Relevant articles from the Web of Science until 31 October 2023 were obtained. Bibliometric analysis of included articles was performed using software (VOSviewer, CiteSpace, and Bibliometrix). The volume and citation of publications, as well as the country, institution, author, journal, keywords of the articles were used as variables to analyze the research trends and hot spot evolution. 1,118 literature from 2008 to 2023 were retrieved from database, with 25 countries/regions, 793 institutions, 5,426 authors, 261 journals involved. Global cooperation was centered on China, Japan, and the United States. Zhengzhou University, an institution from China, had the highest publication. The most prolific author was Guo Wei, and the most prolific journal was Oncology Letters. Analysis of keywords revealed that the research in this field revolved around the role of ncRNAs in the occurrence, development, diagnosis, treatment, and prognosis of ESCC, mainly including micro RNAs, long non-coding RNAs, and then circular RNAs. Overall, research on ncRNAs in ESCC remains strong. Previous research has mainly focused on the basic research, with a focus on the mechanism of ncRNAs in the occurrence, development, diagnosis, treatment, and prognosis of ESCC. Combining current research with emerging disciplines to further explore its mechanisms of action or shifting the focus of research from preclinical research to clinical research based on diagnosis, treatment, and prognosis, will be the main breakthrough in this field in the future.
总结近年来食管鳞癌（ESCC）中非编码 RNA（ncRNA）研究的进展和热点演变，并预测未来的研究方向。检索 2008 年至 2023 年 10 月 31 日 Web of Science 数据库中的相关文章。使用软件（VOSviewer、CiteSpace 和 Bibliometrix）对纳入的文章进行计量学分析。以出版物的数量和引用量，以及文章的国家、机构、作者、期刊、关键词等变量，分析研究趋势和热点演变。从数据库中检索到 2008 年至 2023 年的 1118 篇文献，涉及 25 个国家/地区、793 个机构、5426 名作者、261 种期刊。全球合作以中国、日本和美国为中心。来自中国的郑州大学发表的文献最多。最有影响力的作者是郭伟，最有影响力的期刊是《肿瘤学杂志》。关键词分析显示，该领域的研究集中在 ncRNA 在 ESCC 的发生、发展、诊断、治疗和预后中的作用，主要包括 microRNAs、长链非编码 RNA，然后是环状 RNA。总的来说，ESCC 中 ncRNA 的研究仍然很强劲。以前的研究主要集中在基础研究上，主要关注 ncRNAs 在 ESCC 的发生、发展、诊断、治疗和预后中的作用机制。结合当前的研究和新兴学科，进一步探索其作用机制，或者将研究重点从临床前研究转移到基于诊断、治疗和预后的临床研究，将是该领域未来的主要突破。
