Institut Jacques Monod, CNRS, Université Paris Cité , Paris, France.
J Cell Biol. 2024 Apr 1;223(4). doi: 10.1083/jcb.202403003. Epub 2024 Mar 8.
Centrosome maturation relies on the assembly of an underlying molecular scaffold. In this issue of JCB, Rios et al. (https://doi.org/10.1083/jcb.202306142) use cross-linking mass spectrometry to reveal how PLK-1 phosphorylation promotes intermolecular SPD-5 self-association that is essential for scaffold formation.
中心体成熟依赖于底层分子支架的组装。在本期 JCB 中,Rios 等人(https://doi.org/10.1083/jcb.202306142)使用交联质谱法揭示了 PLK-1 磷酸化如何促进 SPD-5 分子间的自我缔合,这对于支架形成是必不可少的。