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阿米巴肝脓肿:针对一种古老病原体的新型诊断技术的潜在应用

Amoebic Liver Abscess: Potential Application of New Diagnostic Techniques for an Old Pathogen.

作者信息

Portunato Federica, Bartalucci Claudia, Vena Antonio, Giacobbe Daniele Roberto, Porcile Elisa, Montanelli Paolo, Piol Nataniele, Centanaro Monica, Andorno Enzo, Bassetti Matteo

机构信息

Infectious Disease Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Largo Rosanna Benzi, 10, 16132, Genoa, GE, Italy.

Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genova, Genoa, Italy.

出版信息

Infect Dis Ther. 2024 Mar;13(3):625-632. doi: 10.1007/s40121-024-00934-1. Epub 2024 Mar 8.

Abstract

Amoebic liver abscess is a severe and potentially life-threatening infection requiring prompt diagnosis and early targeted treatment. Diagnosis is challenging because conventional diagnostic methods such as light microscopy and serology are often unreliable. Molecular techniques have emerged as an additional diagnostic tool, suddenly becoming the new diagnostic reference standard. More recently, commercial multiplex PCR panels, including FilmArray, have been introduced, which permit the simultaneous detection of several enteric pathogens including Entamoeba histolytica in stool samples. We report a case of an amoebic liver abscess promptly diagnosed by FilmArray gastrointestinal panel performed on liver drainage fluid.

摘要

阿米巴肝脓肿是一种严重且可能危及生命的感染,需要及时诊断和早期针对性治疗。诊断具有挑战性,因为诸如光学显微镜检查和血清学等传统诊断方法往往不可靠。分子技术已成为一种额外的诊断工具,突然成为新的诊断参考标准。最近,包括FilmArray在内的商用多重聚合酶链反应(PCR)检测板已被引入,其可同时检测粪便样本中的几种肠道病原体,包括溶组织内阿米巴。我们报告了一例通过对肝引流液进行FilmArray胃肠道检测板而迅速诊断出的阿米巴肝脓肿病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bf9/10965846/0faef2b763c3/40121_2024_934_Fig1_HTML.jpg

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