药物向中枢神经系统的递送。
Drug delivery to the central nervous system.
作者信息
Nance Elizabeth, Pun Suzie H, Saigal Rajiv, Sellers Drew L
机构信息
Department of Chemical Engineering, University of Washington, Seattle, WA, USA.
These authors contributed equally: Elizabeth Nance, Suzie H. Pun, Rajiv Saigal, Drew L. Sellers.
出版信息
Nat Rev Mater. 2022 Apr;7(4):314-331. doi: 10.1038/s41578-021-00394-w. Epub 2021 Dec 3.
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug development remains challenging, with high costs, long pathways to clinical use and high failure rates. The CNS is highly protected by physiological barriers, in particular, the blood-brain barrier and the blood-cerebrospinal fluid barrier, which limit access of most drugs. Biomaterials can be designed to bypass or traverse these barriers, enabling the controlled delivery of drugs into the CNS. In this Review, we first examine the effects of normal and diseased CNS physiology on drug delivery to the brain and spinal cord. We then discuss CNS drug delivery designs and materials that are administered systemically, directly to the CNS, intranasally or peripherally through intramuscular injections. Finally, we highlight important challenges and opportunities for materials design for drug delivery to the CNS and the anticipated clinical impact of CNS drug delivery.
尽管全球中枢神经系统（CNS）疾病的发病率不断上升，但CNS药物开发仍然具有挑战性，存在成本高、临床应用途径漫长以及失败率高等问题。CNS受到生理屏障的高度保护，特别是血脑屏障和血脑脊液屏障，这限制了大多数药物的进入。生物材料可以设计成绕过或穿过这些屏障，从而实现药物向CNS的可控递送。在本综述中，我们首先研究正常和患病的CNS生理学对药物向脑和脊髓递送的影响。然后，我们讨论通过全身给药、直接向CNS给药、鼻内给药或通过肌肉注射进行外周给药的CNS药物递送设计和材料。最后，我们强调了用于CNS药物递送的材料设计面临的重要挑战和机遇，以及CNS药物递送预期的临床影响。
Zotero 插件