在光混合营养条件下构建木糖利用蓝细菌底盘用于生物生产。
Construction of Xylose-Utilizing Cyanobacterial Chassis for Bioproduction Under Photomixotrophic Conditions.
机构信息
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin, People's Republic of China.
Key Laboratory of Systems Bioengineering and Frontier Science Center of Synthetic Biology, The Ministry of Education of China, Tianjin University, Tianjin, People's Republic of China.
出版信息
Methods Mol Biol. 2024;2760:57-75. doi: 10.1007/978-1-0716-3658-9_4.
Xylose is a major component of lignocellulose and the second most abundant sugar present in nature after glucose; it, therefore, has been considered to be a promising renewable resource for the production of biofuels and chemicals. However, no natural cyanobacterial strain is known capable of utilizing xylose. Here, we take the fast-growing cyanobacteria Synechococcus elongatus UTEX 2973 as an example to develop the synthetic biology-based methodology of constructing a new xylose-utilizing cyanobacterial chassis with increased acetyl-CoA for bioproduction.
木糖是木质纤维素的主要成分，也是自然界中仅次于葡萄糖的第二大丰富糖；因此，它被认为是生产生物燃料和化学品的有前途的可再生资源。然而，目前还没有已知的天然蓝藻菌株能够利用木糖。在这里，我们以快速生长的蓝藻集胞藻 UTEX 2973 为例，开发基于合成生物学的方法，构建具有更多乙酰辅酶 A 的新型木糖利用蓝藻底盘，用于生物生产。
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