Division of Surgical Oncology, DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Oncoimmunology. 2024 Mar 12;13(1):2326694. doi: 10.1080/2162402X.2024.2326694. eCollection 2024.
Pancreatic cancer is characterized by extreme therapeutic resistance. In pancreatic cancers harboring high-risk genomes, we describe that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane (tm)TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T-cell dysfunction - two hallmarks of therapeutic resistance. Targeting tmTNF-TNFR2 signaling may sensitize pancreatic cancer to chemo±immunotherapy.
胰腺癌的特点是治疗耐药性极强。在高危基因组的胰腺癌中，我们描述了癌细胞-中性粒细胞信号通路引发中性粒细胞衍生的跨膜（tm）TNF-TNFR2 相互作用，从而决定了肿瘤相关成纤维细胞和 T 细胞功能障碍的炎症极化——这是治疗耐药性的两个标志。靶向 tmTNF-TNFR2 信号可能使胰腺癌对化疗±免疫治疗更敏感。
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