Li Junping, Hu Hong, Lian Kai, Zhang Dongdong, Hu Pengchao, He Zhibing, Zhang Zhenfeng, Wang Yong
Department of Radiology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei, 441000, China.
Department of Orthopedics, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei, 441000, China.
Heliyon. 2024 Feb 29;10(5):e27196. doi: 10.1016/j.heliyon.2024.e27196. eCollection 2024 Mar 15.
Various preclinical and a limited number of clinical studies of CAR-NK cells have shown promising results: efficient elimination of target cells without side effects similar to CAR-T therapy. However, the homing and infiltration abilities of CAR-NK cells are poor due to the inhibitory tumor microenvironment. From the perspective of clinical treatment strategies, combined with the biological and tumor microenvironment characteristics of NK cells, CAR-NK combination therapy strategies with anti-PD-1/PD-L1, radiotherapy and chemotherapy, kinase inhibitors, proteasome inhibitors, STING agonist, oncolytic virus, photothermal therapy, can greatly promote the proliferation, migration and cytotoxicity of the NK cells. In this review, we will summarize the targets selection, structure constructions and combinational therapies of CAR-NK cells for tumors to provide feasible combination strategies for overcoming the inhibitory tumor microenvironment and improving the efficacy of CAR-NK cells.
多项关于嵌合抗原受体自然杀伤细胞（CAR-NK细胞）的临床前研究及有限数量的临床研究已显示出有前景的结果：能有效消除靶细胞且无类似于CAR-T疗法的副作用。然而，由于肿瘤微环境具有抑制作用，CAR-NK细胞的归巢和浸润能力较差。从临床治疗策略的角度来看，结合NK细胞的生物学特性和肿瘤微环境特点，CAR-NK与抗PD-1/PD-L1、放疗和化疗、激酶抑制剂、蛋白酶体抑制剂、STING激动剂、溶瘤病毒、光热疗法的联合治疗策略，可极大地促进NK细胞的增殖、迁移和细胞毒性。在本综述中，我们将总结CAR-NK细胞用于肿瘤治疗的靶点选择、结构构建及联合治疗方法，以提供可行的联合策略，用于克服肿瘤微环境的抑制作用并提高CAR-NK细胞的疗效。
