饮食总抗氧化能力与听力损失的关系：来自德黑兰员工队列研究的结果。
The association between dietary total antioxidant capacity and hearing loss: results from the Tehran employees Cohort Study.
机构信息
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
BMC Public Health. 2024 Mar 15;24(1):818. doi: 10.1186/s12889-024-18108-6.
BACKGROUND
Despite numerous studies that have explored the association between individual antioxidants or specific combinations and the risk of hearing loss, there is lack of information regarding the relationship between dietary total antioxidant capacity (dTAC) and hearing loss. The conflicting results on this association further highlight the need for more research in this area. This study aims to investigate the association between overall dietary antioxidant intake and the risk of hearing loss among Iranian adults.
METHODS
This cross-sectional study recruited 3443 adult participants aged between 19 and 67 years (with an average age of 41.4 years ± 8.8) who were employed at Tehran University of Medical Sciences in Iran. Participants underwent dietary assessment using a validated Food Frequency Questionnaire (FFQ). The hearing status of each participant was evaluated by a licensed audiologist in a soundproof room, using diagnostic audiometry that adhered to American National Standards specifications and followed standard audiometric clinical procedures. The dietary total antioxidant capacity (dTAC) was calculated using the Ferric Reducing-Antioxidant Power (FRAP) values.
RESULTS
43.6% of male participants had hearing loss, while 26.8% among female participants. After accounting for various confounding factors, no significant association was observed between higher levels of dTAC and reduced odds of hearing loss in the overall population. However, among men under the age of 40, higher levels of dTAC were associated with decreased odds of hearing loss, even after adjusting for several covariates (OR: 0.56, 95% CI: 0.31-1.02, Ptrend = 0.02). This relationship was not evident in men over 40 years of age or among women.
CONCLUSION
The study found an inverse relationship between higher antioxidant intake in the diet and lower odds of hearing loss, specifically among men who were 40 years old or younger. However, this relationship was not observed in the overall population or among women. Additional prospective studies are necessary to validate these results.
背景
尽管有许多研究探讨了个体抗氧化剂或特定组合与听力损失风险之间的关系，但关于饮食总抗氧化能力（dTAC）与听力损失之间的关系，信息仍然缺乏。关于这种关联的相互矛盾的结果进一步强调了在这一领域进行更多研究的必要性。本研究旨在调查伊朗成年人整体饮食抗氧化剂摄入量与听力损失风险之间的关系。
方法
这是一项横断面研究，共招募了 3443 名年龄在 19 至 67 岁之间（平均年龄为 41.4 岁±8.8 岁）的成年参与者，他们在伊朗德黑兰医科大学工作。参与者使用经过验证的食物频率问卷（FFQ）进行饮食评估。每位参与者的听力状况由经过认证的听力学家在隔音室内使用符合美国国家标准规范的诊断测听进行评估，并遵循标准听力临床程序。饮食总抗氧化能力（dTAC）是使用铁还原抗氧化能力（FRAP）值计算的。
结果
43.6%的男性参与者有听力损失，而女性参与者中有 26.8%。在考虑了各种混杂因素后，在总体人群中，较高水平的 dTAC 与听力损失风险降低之间没有显著关联。然而，在 40 岁以下的男性中，较高水平的 dTAC 与听力损失风险降低有关，即使在调整了几个协变量后（OR：0.56，95%CI：0.31-1.02，Ptrend=0.02）。在 40 岁以上的男性或女性中，这种关系并不明显。
结论
该研究发现，饮食中抗氧化剂摄入量较高与听力损失风险降低之间存在反比关系，尤其是在 40 岁或以下的男性中。然而，在总体人群或女性中，没有观察到这种关系。需要进行更多的前瞻性研究来验证这些结果。
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