8-氮杂香豆素衍生物作为光解保护基团的双光子激发效应。

Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups.

机构信息

Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU).

Department of Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University.

出版信息

Chem Pharm Bull (Tokyo). 2024;72(3):311-312. doi: 10.1248/cpb.c24-00013.

DOI:10.1248/cpb.c24-00013

PMID:38494724

Abstract

An improvement of the two-photon excitation was achieved using 8-azacoumarin-type caged compounds, which showed large values of the two-photon uncaging action cross-section (δ >0.1 Goeppert-Mayer (GM)). In particular, the 7-hydroxy-6-iodo-8-azacoumarin (8-aza-Ihc)-caged compound showed an excellent uncaging action cross-section value (δ = 1.28 GM). Therefore, 8-azacoumarin-type photolabile protecting groups (PPGs) can be used as two-photon excitation sources.

摘要

采用 8-氮杂香豆素型笼形化合物提高了双光子激发效率，其双光子光解作用的有效截面（δ>0.1 个戈埃普特-迈耶单位（GM））值较大。特别是，7-羟基-6-碘-8-氮杂香豆素（8-aza-Ihc）-笼形化合物表现出优异的光解作用有效截面值（δ=1.28 GM）。因此，8-氮杂香豆素型光解保护基团（PPG）可用作双光子激发源。