口服寡肽制剂和运动干预对老年人肌少症的影响：一项随机对照试验。
Effects of oral oligopeptide preparation and exercise intervention in older people with sarcopenia: a randomized controlled trial.
机构信息
Department of Clinical Nutrition, West China Hospital, Sichuan University, Sichuan Province, Chengdu, China.
National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
出版信息
BMC Geriatr. 2024 Mar 18;24(1):260. doi: 10.1186/s12877-024-04860-2.
BACKGROUND
Nutrition and exercise are important interventions for sarcopenia. There were few studies on oral oligopeptide nutrition preparations combined with exercise to intervene in the older people with sarcopenia. The aim of this study was to verify the effectiveness of oligopeptide nutrition preparation combined with exercise intervention on the older people with sarcopenia in community.
METHODS
A total of 219 subjects aged 65 years or older with sarcopenia were randomly divided into 4 groups. The nutrition group (n = 58) was given individualized nutrition education and oral oligopeptide nutrition preparation. The exercise group (n = 50) received exercise intervention. The combined group (n = 52) received both oral nutrition preparation and exercise interventions. The control group (n = 59) only received individualized nutrition education. The nutrition preparation can provide energy 185kcal and protein 24.2g per day. The exercise intervention including warm-up exercise, resistance exercise and aerobic exercise, the training time was 60min for 5 times every week. The intervention lasted for 16 weeks. Hand grip strength, gait speed, body composition and hematology parameters were measured before and after intervention.
RESULTS
A total of 159 subjects completed the study. Compared with baseline, the left grip strength and 6-m walking speed of the subjects in nutrition group increased significantly after the intervention, and the grip strength of both hands in exercise group and combined group increased significantly. The body weight of the subjects in nutrition group, exercise group and combined group increased significantly after intervention, but no increase in soft lean mass (SLM) and skeletal muscle mass (SMM) was observed in any of the four groups. The fat-free mass (FFM) of the legs of the control group, exercise group and nutrition group decreased after intervention, and only the FFM of the legs of the combined group maintained the level before the intervention.
CONCLUSION
Both oral peptide nutrition and exercise interventions can improve the muscle strength or function of the older people with sarcopenia. However, there were no increases in muscle mass observed.
TRIAL REGISTRATION
ChiCTR, ChiCTR2100052135. Registered 20 October 2021, https://www.chictr.org.cn/showproj.html?proj=135743.
背景
营养和运动是肌少症的重要干预措施。关于口服寡肽营养制剂联合运动干预老年人肌少症的研究较少。本研究旨在验证口服寡肽营养制剂联合运动干预对社区老年人肌少症的有效性。
方法
共纳入 219 名 65 岁及以上肌少症老年人，随机分为 4 组。营养组（n=58）给予个体化营养教育和口服寡肽营养制剂。运动组（n=50）接受运动干预。联合组（n=52）接受口服营养制剂和运动干预。对照组（n=59）仅接受个体化营养教育。营养制剂每天可提供 185kcal 能量和 24.2g 蛋白质。运动干预包括热身运动、阻力运动和有氧运动，每周训练 5 次，每次 60min。干预持续 16 周。干预前后测量握力、步态速度、身体成分和血液学参数。
结果
共有 159 名受试者完成了研究。与基线相比，营养组受试者的左握力和 6 米步行速度在干预后显著增加，运动组和联合组的双手握力均显著增加。营养组、运动组和联合组受试者的体重在干预后均显著增加，但四组均未观察到瘦体质量（SLM）和骨骼肌质量（SMM）增加。对照组、运动组和营养组受试者的腿部无脂肪质量（FFM）在干预后减少，只有联合组的腿部 FFM 维持了干预前的水平。
结论
口服肽营养和运动干预均可改善肌少症老年人的肌肉力量或功能，但未观察到肌肉质量增加。
试验注册
ChiCTR，ChiCTR2100052135。注册于 2021 年 10 月 20 日，https://www.chictr.org.cn/showproj.html?proj=135743。
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