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本文引用的文献

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[Comparative Study of Induced Pregnancies and Spontaneous Pregnancies in a Level II Hospital in Bamako District Mali].[马里巴马科区一家二级医院诱导妊娠与自然妊娠的比较研究]
Mali Med. 2019;34(3):6-11.
2
Preterm Birth in Assisted Reproductive Technology: An Analysis of More Than 20,000 Singleton Newborns.辅助生殖技术中的早产儿：对 20000 余例单胎新生儿的分析。
Front Endocrinol (Lausanne). 2020 Oct 7;11:558819. doi: 10.3389/fendo.2020.558819. eCollection 2020.
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Methodological sheet n°1: How to calculate the size of a sample for an observational study?方法说明第1号：如何计算观察性研究的样本量？
Tunis Med. 2020 Jan;98(1):1-7.
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Medically assisted reproduction and the risk of preterm birth: a case-control study using data from the Quebec Pregnancy Cohort.医学辅助生殖与早产风险：一项基于魁北克妊娠队列数据的病例对照研究。
CMAJ Open. 2020 Mar 19;8(1):E206-E213. doi: 10.9778/cmajo.20190082. Print 2020 Jan-Mar.
5
Maternal age and risk of low birth weight and premature birth in children conceived through medically assisted reproduction. Evidence from Finnish population registers.母亲年龄与医学辅助生殖所生育儿童的低出生体重和早产风险。来自芬兰人口登记处的证据。
Hum Reprod. 2020 Jan 1;35(1):212-220. doi: 10.1093/humrep/dez275.
6
Assisted reproduction and risk of preterm birth in singletons by infertility diagnoses and treatment modalities: a population-based study.辅助生殖与不孕诊断和治疗方式对单胎早产风险的影响：基于人群的研究。
J Assist Reprod Genet. 2017 Nov;34(11):1529-1535. doi: 10.1007/s10815-017-1003-6. Epub 2017 Jul 28.
7
Intrinsically Defective Microtubule Dynamics Contribute to Age-Related Chromosome Segregation Errors in Mouse Oocyte Meiosis-I.内在缺陷的微管动力学导致小鼠卵母细胞减数分裂 I 中与年龄相关的染色体分离错误。
Curr Biol. 2017 Apr 3;27(7):1040-1047. doi: 10.1016/j.cub.2017.02.025.
8
Perinatal outcomes by mode of assisted conception and sub-fertility in an Australian data linkage cohort.澳大利亚数据关联队列中辅助受孕方式和亚生育状态的围产期结局
PLoS One. 2014 Jan 8;9(1):e80398. doi: 10.1371/journal.pone.0080398. eCollection 2014.
9
[Follow-up of children conceived by assisted reproductive technologies].[辅助生殖技术受孕儿童的随访]
Arch Pediatr. 2013 May;20(5):575-9. doi: 10.1016/j.arcped.2013.02.003. Epub 2013 Mar 30.
10
Adverse obstetric and perinatal outcomes of singleton pregnancies may be related to maternal factors associated with infertility rather than the type of assisted reproductive technology procedure used.单胎妊娠的不良产科和围产期结局可能与与不孕相关的母体因素有关，而不是与所使用的辅助生殖技术类型有关。
Fertil Steril. 2012 Oct;98(4):922-8. doi: 10.1016/j.fertnstert.2012.05.049. Epub 2012 Jul 2.

喀麦隆体外受精后出生的儿童早产风险。

The risk of prematurity in Cameroonian children born after in vitro fertilisation.

机构信息

Department of Pediatrics, University of Yaoundé 1, Cameroon.

Pan African University Institute for Life and Earth Sciences (Including Health and Agriculture), PAULESI, University of Ibadan, Ibadan, Nigeria.

出版信息

Ghana Med J. 2023 Jun;57(2):122-127. doi: 10.4314/gmj.v57i2.6.

DOI:10.4314/gmj.v57i2.6
PMID:38504759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10846651/
Abstract

OBJECTIVE

To evaluate the risk of prematurity in Cameroonian children born after in vitro Fertilisation.

DESIGN

A retrospective cohort study.

SETTING

Conducted at the pediatric department of the Hospital Center for Research and Application in Endoscopic Surgery and Human Reproduction (HCRAESHR) in Yaoundé over eight months.

PARTICIPANTS

Every newborn born after in vitro fertilisation (exposed group) and those born after spontaneous conception (non-exposed group) from a singleton pregnancy were included. Multiple pregnancies were excluded. One hundred newborns per group were recruited and matched according to the mode of delivery.

INTERVENTIONS

The main outcome measure was prematurity at birth. Data were collected from the medical records of the newborns and reported on individual questionnaires. The t Student test was used to assess the differences in gestational age between the two groups. The generalised linear model using binomial probability distribution was used for multivariate analysis to determine prematurity risk factors. All results with a p-value ≤ 0.05 were considered statistically significant.

RESULTS

Prematurity was significantly predominant in the exposed group (22% and 5%, respectively, p=0.002) compared to the non-exposed group. The risk of prematurity in the exposed group was 4.4 times higher than in the non-exposed group. After controlling for confounders (the maternal age, the sex of the baby, and maternal hypertension), this risk increased significantly from 4.4 to 7.67 (p=0.001).

CONCLUSION

This study demonstrated the first evidence from our part of the world showing that in vitro fertilisation is an absolute risk of prematurity.

FUNDING

None declared.

摘要

目的

评估喀麦隆体外受精后出生的儿童早产的风险。

设计

回顾性队列研究。

地点

在雅温得的内镜外科和人类生殖研究与应用中心（HCRAESHR）儿科进行，历时八个月。

参与者

纳入每例体外受精后出生的新生儿（暴露组）和自然受孕后出生的新生儿（非暴露组），均为单胎妊娠。排除多胎妊娠。每组招募 100 名新生儿，根据分娩方式进行匹配。

干预措施

主要结局指标为出生时早产。从新生儿的病历中收集数据，并在个人问卷上报告。采用 t 检验评估两组之间的胎龄差异。使用二项概率分布的广义线性模型进行多变量分析，以确定早产的危险因素。所有 p 值≤0.05 的结果均被认为具有统计学意义。

结果

与非暴露组（分别为 22%和 5%，p=0.002）相比，暴露组早产明显更为常见。与非暴露组相比，暴露组早产的风险高 4.4 倍。在控制混杂因素（母亲年龄、婴儿性别和母亲高血压）后，这种风险显著增加，从 4.4 倍增加到 7.67 倍（p=0.001）。

结论

本研究首次从我们所在地区的角度证明，体外受精是早产的绝对风险。

资金

无。