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探索枯草芽孢杆菌:生态学、生物技术应用及未来展望。

Exploring Bacillus subtilis: Ecology, biotechnological applications, and future prospects.

机构信息

School of Chemical Engineering, University of Birmingham, Birmingham, UK.

The Green Microbiology Lab, University of Birmingham, Birmingham, UK.

出版信息

J Basic Microbiol. 2024 Jun;64(6):e2300614. doi: 10.1002/jobm.202300614. Epub 2024 Mar 20.

Abstract

From its early identification by Christian Gottfried Ehrenberg to its current prominence in scientific research, Bacillus subtilis (B. subtilis) has emerged as a foundational model organism in microbiology. This comprehensive review delves deep into its genetic, physiological, and biochemical intricacies, revealing a sophisticated cellular blueprint. With the incorporation of advanced techniques such as clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 and integrative computational methodologies, the potential applications of B. subtilis span diverse sectors. These encompass its significant contributions to biotechnology, agriculture, and medical fields and its potential for aiding environmental cleanup efforts. Yet, as we move forward, we must grapple with concerns related to safety, ethics, and the practical implementation of our lab findings in everyday scenarios. As our understanding of B. subtilis deepens, it is evident that its contributions will be central to pioneering sustainable solutions for global challenges in the years to come.

摘要

从克里斯蒂安·戈特弗里德·埃伦贝格(Christian Gottfried Ehrenberg)早期的鉴定,到现在在科学研究中的突出地位,枯草芽孢杆菌(Bacillus subtilis,B. subtilis)已成为微生物学中的基础模式生物。本综述深入探讨了其遗传、生理和生化复杂性,揭示了一个复杂的细胞蓝图。随着诸如簇状规律间隔短回文重复序列/CRISPR 相关蛋白 9 和集成计算方法等先进技术的引入,枯草芽孢杆菌的潜在应用涵盖了多个领域。这些应用包括其在生物技术、农业和医学领域的重要贡献,以及在环境清理工作中提供帮助的潜力。然而,当我们向前迈进时,我们必须应对与安全、伦理以及在日常场景中实际实施实验室发现相关的问题。随着我们对枯草芽孢杆菌的理解加深,可以肯定的是,它的贡献将成为未来几年应对全球挑战的可持续解决方案的核心。

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