蛋白质N端乙酰化正进入降解的终局。 - Suppr

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Protein N-terminal acetylation is entering the degradation end game.

作者信息

Arnesen Thomas, Kjosås Ine, McTiernan Nina

机构信息

Department of Biomedicine, University of Bergen, Bergen, Norway.

Department of Surgery, Haukeland University Hospital, Bergen, Norway.

出版信息

Nat Rev Mol Cell Biol. 2024 May;25(5):335-336. doi: 10.1038/s41580-024-00723-1.

DOI:10.1038/s41580-024-00723-1

PMID:38519774

Abstract

摘要

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Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization.

Sci Adv. 2021 Jan 15;7(3). doi: 10.1126/sciadv.abc8590. Print 2021 Jan.

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.

Mol Cell. 2019 Mar 21;73(6):1097-1114. doi: 10.1016/j.molcel.2019.02.007. Epub 2019 Mar 13.

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相似文献

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Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):358-366. doi: 10.1073/pnas.1816596116.

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Mol Cell. 2018 May 3;70(3):488-501.e5. doi: 10.1016/j.molcel.2018.03.033.

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Cell. 2014 Jan 16;156(1-2):158-69. doi: 10.1016/j.cell.2013.11.031. Epub 2013 Dec 19.

Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.

Mol Cell. 2013 May 23;50(4):540-51. doi: 10.1016/j.molcel.2013.03.018. Epub 2013 Apr 18.

N-terminal acetylation of cellular proteins creates specific degradation signals.

Science. 2010 Feb 19;327(5968):973-7. doi: 10.1126/science.1183147. Epub 2010 Jan 28.