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耐万古霉素:一例细菌性心内膜炎病例报告及该病原体所致感染的文献综述

Vancomycin-Resistant : A Case Report of Bacterial Endocarditis and Review of Literature on Infections Caused by This Pathogen.

作者信息

Chiorescu Roxana Mihaela, Buksa Sandor Botond, Botan Alexandru, Mocan Mihaela, Costache Carmen, Toc Dan Alexandru

机构信息

Department of Internal Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

1st Medical Clinic, Internal Medicine Department, Emergency Clinical County Hospital, 400006 Cluj-Napoca, Romania.

出版信息

Microorganisms. 2024 Mar 12;12(3):566. doi: 10.3390/microorganisms12030566.

Abstract

is a rare species, part of the viridans streptococcus group, found initially in rabbits and pigs, which can be vancomycin-resistant. We present the case of a 65-year-old patient, a smoker and chronic alcohol consumer with chronic obstructive pulmonary disease (COPD) and multiple dental foci who had been diagnosed with bacterial endocarditis caused by . The particular elements of the case consisted of an atypical clinical presentation with diarrheal stools, abdominal pain, concomitant damage to the aortic and tricuspid valves, the presence of large vegetations (>2 cm), and a vancomycin-resistant strain of . The evolution of the patient was unfavorable due to septic embolisms, respiratory failure requiring orotracheal intubation, and septic and cardiogenic shock. Infections with are challenging to treat because of the severity of the clinical form it causes and the pattern of antibiotic resistance in this germ. Based on our brief review, is an extremely rare human pathogen previously described as the etiologic agent of infectious endocarditis in only one case.

摘要

是一种罕见物种,属于草绿色链球菌群,最初在兔子和猪身上发现,可能对万古霉素耐药。我们报告一例65岁患者,该患者有吸烟和长期饮酒史,患有慢性阻塞性肺疾病(COPD)且有多个牙病灶,被诊断为由 引起的细菌性心内膜炎。该病例的特殊之处包括非典型临床表现,如腹泻性大便、腹痛、主动脉瓣和三尖瓣同时受损、存在大的赘生物(>2 cm)以及耐万古霉素菌株 。由于脓毒性栓塞、需要经口气管插管的呼吸衰竭以及感染性和心源性休克,患者病情进展不利。由于 引起的临床症状严重以及该病菌的抗生素耐药模式,感染 很难治疗。根据我们的简要回顾, 是一种极其罕见的人类病原体,此前仅在一例病例中被描述为感染性心内膜炎的病原体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6c/10975471/4362c80bf35e/microorganisms-12-00566-g001.jpg

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