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病毒感染致心血管疾病发病机制的研究进展

A Review on The Pathogenesis of Cardiovascular Disease of Viruses Infection.

机构信息

School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, China.

Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China.

出版信息

Viruses. 2024 Feb 27;16(3):365. doi: 10.3390/v16030365.

Abstract

Members of the family, encompassing the and genera, are implicated in a spectrum of severe human pathologies. These diseases span a diverse spectrum, including hepatitis, vascular shock syndrome, encephalitis, acute flaccid paralysis, and adverse fetal outcomes, such as congenital heart defects and increased mortality rates. Notably, infections by viruses have been associated with substantial cardiovascular compromise, yet the exploration into the attendant cardiovascular sequelae and underlying mechanisms remains relatively underexplored. This review aims to explore the epidemiology of Flaviviridae virus infections and synthesize their cardiovascular morbidities. Leveraging current research trajectories and our investigative contributions, we aspire to construct a cogent theoretical framework elucidating the pathogenesis of -induced cardiovascular injury and illuminate prospective therapeutic avenues.

摘要

黄病毒科的成员包括丙型肝炎病毒属和黄病毒属,与一系列严重的人类病理有关。这些疾病范围广泛,包括肝炎、血管休克综合征、脑炎、急性弛缓性麻痹以及先天性心脏缺陷和死亡率增加等不良胎儿结局。值得注意的是,丙型肝炎病毒感染与严重的心血管损害有关,但对伴随的心血管后遗症和潜在机制的探索仍相对不足。本综述旨在探讨黄病毒科病毒感染的流行病学,并综合其心血管并发症。利用当前的研究轨迹和我们的研究贡献,我们希望构建一个合理的理论框架,阐明丙型肝炎病毒诱导的心血管损伤的发病机制,并阐明潜在的治疗途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f8/10974792/ed4a82d555bc/viruses-16-00365-g001.jpg

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