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绷带型角膜接触镜缓解白内障或/和人工晶状体手术后眼干症恶化的疗效。

The efficacy of bandage contact lens in relieving the aggravation of dry eye disease after complicated cataract or/and IOL surgery.

机构信息

Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang University, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China.

Lemolight Ophthalmology Hospital, Hangzhou, Zhejiang, China.

出版信息

BMC Ophthalmol. 2024 Mar 28;24(1):141. doi: 10.1186/s12886-024-03385-x.

Abstract

PURPOSE

In the present study, we aimed to evaluate the efficacy of the bandage contact lens (BCLs) in the treatment of dry eye disease (DED) after complicated cataract or/and intraocular lens (IOL) surgery.

METHODS

In this retrospective, single-centered, observational study, we collected data from 69 patients who underwent complicated cataract or/and IOL surgery. Of these, 35 cases wore their own BCLs immediately after the operation, while the other 34 cases did not have their own BCLs and were instead covered with gauze. The Ocular Surface Disease Index (OSDI) questionnaire, slit-lamp microscope examination, keratograph analysis, and Schirmer I test were measured at baseline, 1 week and 1 month postoperatively.

RESULTS

In the BCL group, the score of the OSDI questionnaire was significantly decreased at 1 week and 1 month postoperatively compared with baseline levels (P = 0.000, collectively). Moreover, the fluorescein staining score of the BCL group was remarkably decreased 1-week and 1-month postoperatively compared with the non-BCL group (P = 0.000 and P = 0.000, respectively). Furthermore, the redness score of the BCL group was also better compared with the non-BCL group at 1 week and 1 month postoperatively (P = 0.014 and P = 0.004, respectively).

CONCLUSIONS

Complicated cataract or/and IOL surgery would intensify the DED. Early application of BCLs postoperatively improved patients' comfort and alleviated dry eye-related symptoms and signs. Furthermore, this mechanism might involve the acceleration of corneal epithelial healing, the alleviation of ocular stress response and the stabilization of the tear film.

TRIAL REGISTRATION

Trial registration ClinicalTrials, NCT04120389. Registered 10 October 2019-retrospectively registered.

摘要

目的

本研究旨在评估绷带接触镜(BCLs)在复杂白内障或/和人工晶状体(IOL)手术后治疗干眼症(DED)的疗效。

方法

在这项回顾性、单中心、观察性研究中,我们收集了 69 例接受复杂白内障或/和 IOL 手术的患者数据。其中 35 例术后立即佩戴自己的 BCLs,而另 34 例则没有佩戴自己的 BCLs,而是用纱布覆盖。在基线、术后 1 周和 1 个月时,使用眼表疾病指数(OSDI)问卷、裂隙灯显微镜检查、角膜地形图分析和泪液分泌试验(Schirmer I 试验)进行测量。

结果

在 BCL 组,术后 1 周和 1 个月时 OSDI 问卷评分明显低于基线水平(P 值均<0.000)。此外,BCL 组术后 1 周和 1 个月时荧光素染色评分明显低于非 BCL 组(P 值分别为<0.000 和 0.000)。此外,术后 1 周和 1 个月时,BCL 组的眼红评分也优于非 BCL 组(P 值分别为 0.014 和 0.004)。

结论

复杂白内障或/和 IOL 手术后会加重 DED。术后早期应用 BCLs 可提高患者舒适度,缓解干眼相关症状和体征。此外,这种机制可能涉及加速角膜上皮愈合、减轻眼应激反应和稳定泪膜。

试验注册

临床试验,NCT04120389。于 2019 年 10 月 10 日注册-回顾性注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c091/10976755/ab9bb0fa6844/12886_2024_3385_Fig1_HTML.jpg

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