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结核治疗结局及其相关因素分析:来自埃塞俄比亚西北莫塔镇医疗机构的五年回顾性研究。

Tuberculosis treatment outcomes and associated factors among tuberculosis patients treated at healthcare facilities of Motta Town, Northwest Ethiopia: a five-year retrospective study.

机构信息

Department of Pharmaceutics, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

出版信息

Sci Rep. 2024 Apr 2;14(1):7695. doi: 10.1038/s41598-024-58080-0.

Abstract

Tuberculosis (TB) remains a significant public health concern, particularly in low-resource settings. The treatment outcome is a crucial indicator of the effectiveness of TB treatment programs. Assessing the current treatment outcome and its associated factors is essential for improving patient care and reducing the spread of TB. Therefore, this study aimed to assess TB treatment outcomes and their associated factors among TB patients who received treatment at public healthcare facilities in Motta Town, Northwest Ethiopia. A facility-based retrospective cross-sectional study design was employed in two TB treatment centers in Motta town from January 2017 to December 2021. The study participants were all patients diagnosed with TB who received treatment. A p-value of 0.05 with a 95% confidence interval (CI) was used to determine statistical significance. A total of 362 TB patients were included in the study. The overall treatment success rate was 88.4% (95% CI 85.1, 91.7). Male gender (AOR = 2.40, 95% CI 1.16, 4.98), normal nutritional status (AOR = 3.11, 95% CI 1.33, 7.25), HIV negative status (AOR = 3.35, 95% CI 1.31, 8.60), and non-presumptive drug resistance to TB (AOR = 3.72, 95% CI 1.74, 7.98) were significantly associated with successful TB treatment outcomes (p < 0.05). In the current study, nine out of ten study participants had successful TB treatment outcome rates. Male gender, normal nutritional status, non-presumed drug resistance to TB, and HIV-negative status were significantly associated with successful TB treatment outcomes. By taking risk factors associated with poor treatment outcomes like those found in this study into account, patient management and treatment can be optimized. Sufficient TB control measures for populations are imperative and could significantly reduce the nation's total TB burden.

摘要

结核病(TB)仍然是一个重大的公共卫生问题,特别是在资源匮乏的环境中。治疗结果是评估结核病治疗计划有效性的关键指标。评估当前的治疗结果及其相关因素对于改善患者护理和减少结核病的传播至关重要。因此,本研究旨在评估在埃塞俄比亚西北部莫塔镇的公共医疗设施接受治疗的结核病患者的治疗结果及其相关因素。这项研究采用了 2017 年 1 月至 2021 年 12 月在莫塔镇两个结核病治疗中心进行的基于设施的回顾性横断面研究设计。研究参与者均为接受治疗的结核病确诊患者。使用具有 95%置信区间(CI)的 0.05 作为统计显著性的临界值。共有 362 名结核病患者纳入本研究。总体治疗成功率为 88.4%(95%CI 85.1, 91.7)。男性(AOR=2.40, 95%CI 1.16, 4.98)、正常营养状况(AOR=3.11, 95%CI 1.33, 7.25)、HIV 阴性(AOR=3.35, 95%CI 1.31, 8.60)和非推测性结核病药物耐药性(AOR=3.72, 95%CI 1.74, 7.98)与结核病治疗成功结果显著相关(p<0.05)。在本研究中,十分之九的研究参与者结核病治疗结果成功。男性、正常营养状况、非推测性结核病药物耐药性和 HIV 阴性与结核病治疗成功结果显著相关。通过考虑与治疗结果不佳相关的风险因素,如本研究中发现的那些因素,可以优化患者管理和治疗。针对人群实施充分的结核病控制措施至关重要,可以显著减轻国家的结核病负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edf2/10987627/f3d255fd8f94/41598_2024_58080_Fig1_HTML.jpg

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