Saenz de Pipaon Miguel, Nelin Leif D, Gehred Alison, Rossholt Madelaine E, Moltu Sissel, Van den Akker Chris, van Kaam Anton H, Sánchez Ana, Khashu Minesh, Roehr Charles C, Carnielli Virgilio
Department of Neonatology, Instituto de Investigación Sanitaria, La Paz University Hospital-IdiPAZ (Universidad Autonoma), Madrid, Spain.
Comprehensive Center for Bronchopulmonary Dysplasia, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.
Pediatr Res. 2024 Apr 2. doi: 10.1038/s41390-024-03133-3.
Chronic lung disease of prematurity or bronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Nutrition may affect incidence and severity of BPD. In this context, the Section on Nutrition, Gastroenterology and Metabolism, the Pulmonary Section of the European Society for Paediatric Research (ESPR) and SPR have joined forces to review the current knowledge on nutritional issues related to BPD. The aim of this narrative review is to discuss the clinical implications for nutritional practice. Nutrient deficiencies may influence pathogenesis of BPD. Adequate nutrition and growth can play a crucial role in the prevention of and recovery from BPD. Optimal nutrition strategy is an important principle, especially in the early postnatal period. As optimal energy intake in infants at risk of BPD or with evolving BPD is not yet defined, further research with well-designed studies on nutritional strategies for preterm infants with BPD is urgently needed. IMPACT: Based on current evidence it seems reasonable to recommend that BPD diagnosed infants should receive an energy supply ranging from 120 to 150 Kcal/kg/d. Exclusive MOM feed with adequate fortification should be encouraged as this is associated with a significant reduction in the risk of BPD. Suboptimal nutritional delivery is often seen in preterm infants with BPD compared to controls.
早产儿慢性肺部疾病或支气管肺发育不良(BPD)是早产的常见并发症。营养可能会影响BPD的发病率和严重程度。在此背景下,欧洲儿科研究学会(ESPR)的营养、胃肠病学和代谢科以及肺部科与SPR联合起来,对与BPD相关的营养问题的现有知识进行综述。本叙述性综述的目的是讨论营养实践的临床意义。营养缺乏可能会影响BPD的发病机制。充足的营养和生长在预防BPD以及从BPD中恢复方面可发挥关键作用。最佳营养策略是一项重要原则,尤其是在出生后的早期阶段。由于尚未确定有BPD风险或患有进展性BPD的婴儿的最佳能量摄入量,因此迫切需要开展精心设计的关于BPD早产儿营养策略的进一步研究。影响:基于目前的证据,建议诊断为BPD的婴儿应接受120至150千卡/千克/天的能量供应似乎是合理的。应鼓励使用强化适当的纯母乳进行喂养,因为这与BPD风险的显著降低相关。与对照组相比,BPD早产儿中营养供应不足的情况较为常见。