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晚期胆管癌患者姑息治疗的当前介入治疗选择。

Current interventional options for palliative care for patients with advanced-stage cholangiocarcinoma.

作者信息

Makki Maryam, Bentaleb Malak, Abdulrahman Mohammed, Suhool Amal Abdulla, Al Harthi Salem, Ribeiro Marcelo Af

机构信息

Department of Surgery, Division of Trauma, Critical Care and Acute Care Surgery, Sheikh Shakhbout Medical City, Abu Dhabi 11001, United Arab Emirates.

Department of Surgery, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi 11001, United Arab Emirates.

出版信息

World J Clin Oncol. 2024 Mar 24;15(3):381-390. doi: 10.5306/wjco.v15.i3.381.

Abstract

Primary biliary tract tumors are malignancies that originate in the liver, bile ducts, or gallbladder. These tumors often present with jaundice of unknown etiology, leading to delayed diagnosis and advanced disease. Currently, several palliative treatment options are available for primary biliary tract tumors. They include percutaneous transhepatic biliary drainage (PTBD), biliary stenting, and surgical interventions such as biliary diversion. Systemic therapy is also commonly used for the palliative treatment of primary biliary tract tumors. It involves the administration of chemotherapy drugs, such as gemcitabine and cisplatin, which have shown promising results in improving overall survival in patients with advanced biliary tract tumors. PTBD is another palliative treatment option for patients with unresectable or inoperable malignant biliary obstruction. Biliary stenting can also be used as a palliative treatment option to alleviate symptoms in patients with unresectable or inoperable malignant biliary obstruction. Surgical interventions, such as biliary diversion, have traditionally been used as palliative options for primary biliary tract tumors. However, biliary diversion only provides temporary relief and does not remove the tumor. Primary biliary tract tumors often present in advanced stages, making palliative treatment the primary option for improving the quality of life of patients.

摘要

原发性胆道肿瘤是起源于肝脏、胆管或胆囊的恶性肿瘤。这些肿瘤常表现为病因不明的黄疸,导致诊断延迟和疾病进展。目前,原发性胆道肿瘤有几种姑息治疗选择。包括经皮经肝胆道引流(PTBD)、胆道支架置入术以及诸如胆肠吻合术等外科干预措施。全身治疗也常用于原发性胆道肿瘤的姑息治疗。它涉及给予化疗药物,如吉西他滨和顺铂,这些药物在改善晚期胆道肿瘤患者的总生存期方面已显示出有希望的结果。PTBD是不可切除或无法手术的恶性胆道梗阻患者的另一种姑息治疗选择。胆道支架置入术也可作为一种姑息治疗选择,用于缓解不可切除或无法手术的恶性胆道梗阻患者的症状。诸如胆肠吻合术等外科干预措施传统上一直被用作原发性胆道肿瘤的姑息治疗选择。然而,胆肠吻合术仅能提供暂时缓解,无法切除肿瘤。原发性胆道肿瘤常处于晚期,这使得姑息治疗成为改善患者生活质量的主要选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3b/10989261/823bdd01c1b7/WJCO-15-381-g001.jpg

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