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饮食因素及其对肿瘤免疫治疗策略的影响:全面综述。

Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review.

机构信息

Prof. Waclaw Dabrowski Institute of Agricultural and Food Biotechnology State Research Institute, Rakowiecka 36, 02-532, Warsaw, Poland.

Clinical Research Center, Medical University of Bialystok, M. Skłodowskiej-Curie 24a, 15-276, Bialystok, Poland.

出版信息

Cell Death Dis. 2024 Apr 9;15(4):254. doi: 10.1038/s41419-024-06641-6.

Abstract

Immunotherapy is emerging as a promising avenue in oncology, gaining increasing importance and offering substantial advantages when compared to chemotherapy or radiotherapy. However, in the context of immunotherapy, there is the potential for the immune system to either support or hinder the administered treatment. This review encompasses recent and pivotal studies that assess the influence of dietary elements, including vitamins, fatty acids, nutrients, small dietary molecules, dietary patterns, and caloric restriction, on the ability to modulate immune responses. Furthermore, the article underscores how these dietary factors have the potential to modify and enhance the effectiveness of anticancer immunotherapy. It emphasizes the necessity for additional research to comprehend the underlying mechanisms for optimizing the efficacy of anticancer therapy and defining dietary strategies that may reduce cancer-related morbidity and mortality. Persistent investigation in this field holds significant promise for improving cancer treatment outcomes and maximizing the benefits of immunotherapy.

摘要

免疫疗法在肿瘤学领域崭露头角,与化疗或放疗相比,它具有越来越重要的地位和显著的优势。然而,在免疫疗法的背景下,免疫系统可能会支持或阻碍所给予的治疗。这篇综述涵盖了最近的重要研究,评估了饮食元素(包括维生素、脂肪酸、营养素、小膳食分子、饮食模式和热量限制)对调节免疫反应能力的影响。此外,本文强调了这些饮食因素如何有可能改变和增强抗癌免疫疗法的有效性。它强调了需要进一步研究来理解潜在的机制,以优化抗癌治疗的疗效,并确定可能降低癌症相关发病率和死亡率的饮食策略。在该领域的持续研究为改善癌症治疗结果和最大限度地提高免疫疗法的益处提供了巨大的希望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9042/11004013/e550ba12a517/41419_2024_6641_Fig1_HTML.jpg

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