常吃奶制品与前驱糖尿病向正常血糖逆转或进展为 2 型糖尿病的几率：9 年随访研究。
Usual intake of dairy products and the chance of pre-diabetes regression to normal glycemia or progression to type 2 diabetes: a 9-year follow-up.
机构信息
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Nutr Diabetes. 2024 Apr 9;14(1):15. doi: 10.1038/s41387-024-00257-7.
BACKGROUND
We assessed the possible effect of usual dairy consumption on pre-diabetes (Pre-DM) remission or progression to type 2 diabetes (T2D).
METHODS
Pre-DM adults (n = 334, mean age of 49.4 years, and 51.5% men) were assessed for dairy intakes (2006-2008) and followed up to 9 years for incidence of T2D or normal glycemia (NG). All biochemical measurements were done at baseline and all subsequent examinations with 3-y follow-up intervals. Multinomial regression models with adjustment of confounding variables were used to estimate odds ratios (OR) and 95% confidence intervals (CIs) of incident T2D and NG for each serving/d dairy consumption.
RESULTS
The odds of NG was significantly elevated by 69% (OR = 1.69, 95% CI = 1.00-2.86, P = 0.05) per 200 g/d increased high-fat dairy intake, while the amount of total dairy or low-fat dairy was not related to the outcomes. Higher intakes of yogurt were more likely to be associated with an increased odds of NG (OR = 1.82, 95% CI = 1.20-2.74, P = 0.01). Usual intakes of milk, cheese, or cream-butter were not associated to Pre-DM remission or progression to T2D.
CONCLUSION
Regular dairy consumption may increase the chance of Pre-DM regression to NG.
背景
我们评估了常规乳制品摄入对糖尿病前期（Pre-DM）缓解或进展为 2 型糖尿病（T2D）的可能影响。
方法
评估了 334 名 Pre-DM 成年人（平均年龄为 49.4 岁，51.5%为男性）的乳制品摄入量（2006-2008 年），并随访 9 年以了解 T2D 或正常血糖（NG）的发病情况。所有生化测量均在基线时进行，所有后续检查均间隔 3 年进行。采用调整混杂因素的多变量回归模型来估计每种乳制品摄入量与新发 T2D 和 NG 的比值比（OR）和 95%置信区间（CI）。
结果
每增加 200g/d 的高脂肪乳制品摄入量，NG 的可能性显著增加 69%（OR=1.69，95%CI=1.00-2.86，P=0.05），而总乳制品或低脂乳制品的摄入量与结果无关。摄入更多的酸奶更有可能增加 NG 的可能性（OR=1.82，95%CI=1.20-2.74，P=0.01）。常规摄入牛奶、奶酪或奶油黄油与 Pre-DM 缓解或进展为 T2D 无关。
结论
定期摄入乳制品可能会增加 Pre-DM 缓解为 NG 的机会。
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