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微小 RNA 与早产的关联:系统综述。

MicroRNA Associations with Preterm Labor-A Systematic Review.

机构信息

Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-081 Lublin, Poland.

Department of Obstetrics and Perinatology, The University Hospital in Krakow, 30-551 Krakow, Poland.

出版信息

Int J Mol Sci. 2024 Mar 28;25(7):3755. doi: 10.3390/ijms25073755.

Abstract

This systematic review delves into the connections between microRNAs and preterm labor, with a focus on identifying diagnostic and prognostic markers for this crucial pregnancy complication. Covering studies disseminated from 2018 to 2023, the review integrates discoveries from diverse pregnancy-related scenarios, encompassing gestational diabetes, hypertensive disorders and pregnancy loss. Through meticulous search strategies and rigorous quality assessments, 47 relevant studies were incorporated. The synthesis highlights the transformative potential of microRNAs as valuable diagnostic tools, offering promising avenues for early intervention. Notably, specific miRNAs demonstrate robust predictive capabilities. In conclusion, this comprehensive analysis lays the foundation for subsequent research, intervention strategies and improved outcomes in the realm of preterm labor.

摘要

这篇系统综述深入探讨了 microRNAs 与早产之间的关联,重点在于确定这一关键妊娠并发症的诊断和预后标志物。综述涵盖了 2018 年至 2023 年发表的研究,整合了来自不同妊娠相关情况的发现,包括妊娠期糖尿病、高血压疾病和妊娠丢失。通过精心的搜索策略和严格的质量评估,纳入了 47 项相关研究。该综述强调了 microRNAs 作为有价值的诊断工具的变革潜力,为早期干预提供了有前景的途径。值得注意的是,特定的 microRNAs 显示出强大的预测能力。总之,这项全面分析为后续研究、干预策略以及改善早产领域的结局奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21e4/11012198/db0c492ebff5/ijms-25-03755-g001.jpg

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