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Nayara de Souza da Costa, Luíza Siqueira Lima, Maria Eduarda Andrade Galiciolli, Deborah Helen Fabiano Ribeiro, Milena Mariano Ribeiro, Gisele de Paula Júlia Garica, Isabela Saragioto Marçal, Juliana Ferreira da Silva, Meire Ellen Pereira, Cláudia Sirlene Oliveira, Izonete Cristina Guiloski
Instituto de Pesquisas Pelé Pequeno Príncipe, Curitiba 80035-000, Brazil; Faculdades Pequeno Príncipe, Curitiba 80230-020, Brazil.
Instituto de Pesquisas Pelé Pequeno Príncipe, Curitiba 80035-000, Brazil; Faculdades Pequeno Príncipe, Curitiba 80230-020, Brazil.
J Trace Elem Med Biol. 2024 Jul;84:127446. doi: 10.1016/j.jtemb.2024.127446. Epub 2024 Apr 4.
Osteoporosis is associated with an imbalance in bone formation, with certain drugs used in disease treatment being implicated in its development. Supplementation with trace elements may contribute to bone regeneration, offering an alternative approach by enhancing bone mineral density (BMD) and thereby thwarting the onset of osteoporosis. This review aims to assess the mechanisms through which trace elements such as copper (Cu), iron (Fe), selenium (Se), manganese (Mn), and zinc (Zn) are linked to increased bone mass, thus mitigating the effects of pharmaceuticals. Our findings underscore that the use of drugs such as aromatase inhibitors (AIs), proton pump inhibitors (PPIs), antiretrovirals, glucocorticoids, opioids, or anticonvulsants can result in decreased BMD, a primary contributor to osteoporosis. Research indicates that essential elements like Cu, Fe, Se, Mn, and Zn, through various mechanisms, can bolster BMD and forestall the onset of the disease, owing to their protective effects. Consequently, our study recommends a minimum daily intake of these essential minerals for patients undergoing treatment with the aforementioned drugs, as the diverse mechanisms governing the effects of trace elements Cu, Fe, Mn, Se, and Zn facilitate bone remodeling.
骨质疏松症与骨形成失衡有关，某些用于治疗疾病的药物被认为与该病的发生有关。微量元素的补充可能有助于骨再生，通过增强骨矿物质密度（BMD）来提供一种替代方法，从而阻止骨质疏松症的发生。本综述旨在评估铜（Cu）、铁（Fe）、硒（Se）、锰（Mn）和锌（Zn）等微量元素与增加骨量的机制之间的联系，从而减轻药物的影响。我们的研究结果强调，使用芳香酶抑制剂（AIs）、质子泵抑制剂（PPIs）、抗逆转录病毒药物、糖皮质激素、阿片类药物或抗惊厥药等药物会导致 BMD 降低，这是骨质疏松症的主要原因。研究表明，由于这些必需元素具有保护作用，Cu、Fe、Se、Mn 和 Zn 等必需元素通过多种机制可以增强 BMD 并预防疾病的发生。因此，我们的研究建议接受上述药物治疗的患者每天最低摄入这些必需矿物质，因为控制微量元素 Cu、Fe、Mn、Se 和 Zn 作用的机制多样化，有利于骨重塑。
