A possible role of antihypertensive polar renomedullary lipid (APRL) and prostaglandin E2 in the kidney in the antihypertensive action of pindolol.

The influence of the pretreatment with CV-3988, a specific antagonist of antihypertensive polar renomedullary lipid (APRL), and/or indomethacin on the antihypertensive effect of pindolol was examined in order to clarify a possible role of APRL and prostaglandin E2 (PGE2) in the kidney in the effect of pindolol in male spontaneously hypertensive rats (SHR). CV-3988 effectively attenuated the antihypertensive effect of pindolol, although pindolol still significantly lowered blood pressure following CV-3988 treatment. Besides, the pretreatment with CV-3988 showed no significant effect on an increased PGE2 level and a decreased volume of urine after pindolol treatment. The antihypertensive effect of pindolol disappeared after the CV-3988 treatment in combination with indomethacin.