Shanghai Engineering Research Center of Organ Repair, School of Life Sciences, Shanghai University, Shanghai, China.
Institute of Geriatrics, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Front Immunol. 2024 Apr 4;15:1382971. doi: 10.3389/fimmu.2024.1382971. eCollection 2024.
Previous studies have demonstrated an association between lymphatic vessels and diseases caused by bacterial infections. (LM) bacterial infection can affect multiple organs, including the intestine, brain, liver and spleen, which can be fatal. However, the impacts of LM infection on morphological and functional changes of lymphatic vessels remain unexplored. In this study, we found that LM infection not only induces meningeal and mesenteric lymphangiogenesis in mice, but also impairs meningeal lymphatic vessels (MLVs)-mediated macromolecules drainage. Interestingly, we found that the genes associated with lymphatic vessel development and function, such as and , were downregulated, suggesting that LM infection may affect cellular polarization and valve development. On the other hand, photodynamic ablation of MLVs exacerbated inflammation and bacterial load in the brain of mice with LM infection. Overall, our findings indicate that LM infection induces lymphangiogenesis and may affect cell polarization, cavity formation, and valve development during lymphangiogenesis, ultimately impairing MLVs drainage.
先前的研究表明淋巴管与由细菌感染引起的疾病之间存在关联。（LM）细菌感染可影响多个器官，包括肠道、大脑、肝脏和脾脏，这可能是致命的。然而，LM 感染对淋巴管形态和功能变化的影响仍未被探索。在这项研究中，我们发现 LM 感染不仅会诱导小鼠脑膜和肠系膜淋巴管生成，还会损害脑膜淋巴管（MLVs）介导的大分子引流。有趣的是，我们发现与淋巴管发育和功能相关的基因，如 和 ，下调，这表明 LM 感染可能影响细胞极化和瓣膜发育。另一方面，MLVs 的光动力消融加剧了 LM 感染小鼠大脑中的炎症和细菌负荷。总体而言，我们的研究结果表明 LM 感染会诱导淋巴管生成，并可能影响淋巴管生成过程中的细胞极化、腔形成和瓣膜发育，最终损害 MLVs 的引流。
