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腺相关病毒在神经科学中的潜力:简要综述。

Unlocking the potential of adeno-associated virus in neuroscience: a brief review.

机构信息

Neuroscience Institute, National Research Council (CNR), Pisa, Italy.

Department of Biology, Unit of Cell and Developmental Biology, University of Pisa, Pisa, Italy.

出版信息

Mol Biol Rep. 2024 Apr 22;51(1):563. doi: 10.1007/s11033-024-09521-6.

Abstract

Adeno-associated virus (AAV) has emerged as a pivotal tool in neuroscience research, owing to its remarkable versatility and efficiency in delivering genetic material to diverse cell types within the nervous system. This mini review aims to underscore the advanced applications of AAV vectors in neuroscience and their profound potential to revolutionize our understanding of brain function and therapeutic interventions for neurological disorders. By providing a concise overview of the latest developments and strategies employing AAV vectors, this review illuminates the transformative role of AAV technology in unraveling the complexities of neural circuits and paving the way for innovative treatments. Through elucidating the multifaceted capabilities of AAV-mediated gene delivery, this review underscores its pivotal role as a cornerstone in contemporary neuroscience research, promising remarkable insights into the intricacies of brain biology and offering new avenues for therapeutic intervention.

摘要

腺相关病毒(AAV)已成为神经科学研究中的重要工具,因为它能够高效地将遗传物质递送到神经系统中的多种细胞类型中。本篇综述旨在强调 AAV 载体在神经科学中的先进应用,以及它们在深入理解大脑功能和神经疾病治疗干预方面的巨大潜力。通过对 AAV 载体的最新发展和策略的简要概述,本综述阐明了 AAV 技术在揭示神经回路复杂性和为创新治疗方法铺平道路方面的变革作用。通过阐明 AAV 介导的基因传递的多方面能力,本综述强调了它作为当代神经科学研究基石的关键作用,有望为大脑生物学的复杂性提供显著的见解,并为治疗干预提供新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d466/11035420/61422b7230b0/11033_2024_9521_Fig1_HTML.jpg

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