罗伊氏乳杆菌SJ-47菌株胞外多糖对UVA辐射损伤的人皮肤成纤维细胞的保护作用。
Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation.
作者信息
Zhao Jingsha, Fu Hao, Zhang Yongtao, Li Meng, Wang Dongdong, Zhao Dan, Zhang Jiachan, Wang Changtao
机构信息
Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, People's Republic of China.
Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People's Republic of China.
出版信息
Bioresour Bioprocess. 2022 Dec 14;9(1):127. doi: 10.1186/s40643-022-00617-0.
Ultraviolet rays in sunlight can cause skin damage and premature aging. This study demonstrates that Lactobacillus reuteri SJ-47 strain exopolysaccharides (EPS) protect human skin fibroblasts (HSF) under UVA radiation. During the course of the experiments, we investigate the oxidative stress protection and antiaging effects of exopolysaccharides on HSF at the biochemical, cellular, and molecular levels. The results show that EPS can increase the antioxidant capacity of cells, decrease the amount of reactive-oxygen species (ROS) and malondialdehyde (MDA), while improve the expression of antioxidant enzymes. At the same time, EPS can increase collagen content, which can effectively regulate the expression of genes in the senescence and apoptosis pathways, and delay skin photoaging caused by UVA irradiation.
阳光中的紫外线会导致皮肤损伤和过早衰老。本研究表明，罗伊氏乳杆菌SJ-47菌株胞外多糖（EPS）可在紫外线A（UVA）辐射下保护人皮肤成纤维细胞（HSF）。在实验过程中，我们在生化、细胞和分子水平上研究了胞外多糖对HSF的氧化应激保护和抗衰老作用。结果表明，EPS可提高细胞的抗氧化能力，减少活性氧（ROS）和丙二醛（MDA）的含量，同时提高抗氧化酶的表达。同时，EPS可增加胶原蛋白含量，有效调节衰老和凋亡途径中基因的表达，并延缓UVA照射引起的皮肤光老化。
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