Eph/ephrin系统在结直肠癌中的潜在作用：新兴的可成药分子靶点

Potential role of the Eph/ephrin system in colorectal cancer: emerging druggable molecular targets.

作者信息

Scarini João Figueira, Gonçalves Moisés Willian Aparecido, de Lima-Souza Reydson Alcides, Lavareze Luccas, de Carvalho Kimura Talita, Yang Ching-Chu, Altemani Albina, Mariano Fernanda Viviane, Soares Heloisa Prado, Fillmore Gary Chris, Egal Erika Said Abu

机构信息

Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.

出版信息

Front Oncol. 2024 Apr 2;14:1275330. doi: 10.3389/fonc.2024.1275330. eCollection 2024.

DOI:10.3389/fonc.2024.1275330

PMID:38651144

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11033724/

Abstract

The Eph/ephrin system regulates many developmental processes and adult tissue homeostasis. In colorectal cancer (CRC), it is involved in different processes including tumorigenesis, tumor angiogenesis, metastasis development, and cancer stem cell regeneration. However, conflicting data regarding Eph receptors in CRC, especially in its putative role as an oncogene or a suppressor gene, make the precise role of Eph-ephrin interaction confusing in CRC development. In this review, we provide an overview of the literature and highlight evidence that collaborates with these ambiguous roles of the Eph/ephrin system in CRC, as well as the molecular findings that represent promising therapeutic targets.

摘要

Eph/ephrin系统调节许多发育过程和成年组织的稳态。在结直肠癌（CRC）中，它参与不同的过程，包括肿瘤发生、肿瘤血管生成、转移发展和癌症干细胞再生。然而，关于CRC中Eph受体的相互矛盾的数据，特别是其作为癌基因或抑癌基因的假定作用，使得Eph-ephrin相互作用在CRC发展中的精确作用令人困惑。在本综述中，我们概述了文献，并强调了与Eph/ephrin系统在CRC中的这些模糊作用相关的证据，以及代表有前景治疗靶点的分子研究结果。